Chagas disease drug discovery: toward a new era

E Chatelain - Journal of biomolecular screening, 2015 - journals.sagepub.com
American trypanosomiasis, or Chagas disease, is the result of infection by the Trypanosoma
cruzi parasite. Endemic in Latin America where it is the major cause of death from …

Transfusion transmitted Chagas disease: is it really under control?

S Wendel - Acta tropica, 2010 - Elsevier
Transfusion transmitted Chagas disease was recognized as a medical problem more than
50 years ago. However, little attention was paid to it by Transfusion Medicine, medical …

Persistent Biofluid Small-Molecule Alterations Induced by Trypanosoma cruzi Infection Are Not Restored by Parasite Elimination

DA Dean, J Roach, R Ulrich vonBargen… - ACS Infectious …, 2023 - ACS Publications
Chagas disease (CD), caused by Trypanosoma cruzi (T. cruzi) protozoa, is a complicated
parasitic illness with inadequate medical measures for diagnosing infection and monitoring …

Identification of novel diagnostic serum biomarkers for Chagas' disease in asymptomatic subjects by mass spectrometric profiling

M Ndao, TW Spithill, R Caffrey, H Li… - Journal of clinical …, 2010 - Am Soc Microbiol
More than 10 million people are thought to be infected with Trypanosoma cruzi, primarily in
the Americas. The clinical manifestations of Chagas' disease (CD) are variable, but most …

Serum biomarkers predictive of cure in Chagas disease patients after nifurtimox treatment

C Santamaria, E Chatelain, Y Jackson, Q Miao… - BMC infectious …, 2014 - Springer
Background Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, remains
an important public health issue in many Central and South American countries, as well as …

Stairway to heaven or hell? Perspectives and limitations of Chagas disease chemotherapy

K Salomao… - Current Topics in …, 2016 - ingentaconnect.com
In this review, we intend to provide a general view of the evolution of experimental studies in
the area of chemotherapy for Chagas disease. We can follow the process of drug …

Short-term follow-up of chagasic patients after benznidazole treatment using multiple serological markers

A Fernández-Villegas, MJ Pinazo, C Marañón… - BMC infectious …, 2011 - Springer
Background Conventional serological tests, using total soluble proteins or a cocktail of
recombinant proteins from T. cruzi as antigens, are highly sensitive for Chagas disease …

Different serological cross-reactivity of Trypanosoma rangeli forms in Trypanosoma cruzi-infected patients sera

MH de Moraes, AA Guarneri, FP Girardi… - Parasites & vectors, 2008 - Springer
Abstract Background American Trypanosomiasis or Chagas disease is caused by
Trypanosoma cruzi which currently infects approximately 16 million people in the Americas …

Characterization of an immunodominant antigenic epitope from Trypanosoma cruzi as a biomarker of chronic Chagas' disease pathology

MC Thomas, A Fernández-Villegas… - Clinical and Vaccine …, 2012 - Am Soc Microbiol
Nowadays, the techniques available for chronic Chagas' disease diagnosis are very
sensitive; however, they do not allow discrimination of the patient's clinical stages of the …

Estimation of sensitivity and specificity of several Trypanosoma cruzi antibody assays in blood donors in Argentina

MC Remesar, C Gamba, IF Colaianni, M Puppo… - …, 2009 - Wiley Online Library
BACKGROUND: The absence of a gold standard test for Trypanosoma cruzi antibodies
represents a problem not only for the evaluation of screening tests, but also for appropriate …