Copper (Cu) is a vital element required for cellular growth and development; however, even
slight changes in its homeostasis might lead to severe toxicity and deleterious medical …

The advent of Camptothecin added a new dimension in the field anticancer drug
development containing quinoline motif. Quinoline scaffold plays an important role in …

Metal ions play an important role in biological processes and in metal homeostasis. Metal
imbalance is the leading cause for many neurodegenerative diseases such as Alzheimer's …

Cancer is among the leading causes of death worldwide. Although a number of new
treatment options have been developed in recent years, there remains a need for improved …

Hydroxyquinolines are heterocyclic compounds characterized by a moderate metal-binding
affinity. The interest in 8-hydroxyquinolines has grown exponentially in the last two decades …

As we gain a better understanding of the factors affecting cancer etiology, we can design
improved treatment strategies. Over the past three to four decades, there have been …

Chloroquine is an established antimalarial agent that has been recently tested in clinical
trials for its anticancer activity. The favorable effect of chloroquine appears to be due to its …

Highlights•Disulfiram, an anti-alcoholism drug, was found owing anti-tumor activity.•The
combination of Disulfiram and copper greatly enhances its anti-tumor efficacy.•Disulfiram in …

The human prostate gland contains extremely high zinc levels; which is due to the
specialized zinc-accumulating acinar epithelial of the peripheral zone. These cells evolved …

Copper-containing coordination compounds attract wide attention due to the redox activity
and biogenicity of copper ions, providing multiple pathways of biological activity. The …