Riboswitches are structured non-coding RNAs found in the 5′ UTR of important genes for
bacterial metabolism, virulence and survival. Upon the binding of specific ligands that can …

Antimicrobial drug resistance has emerged as a significant challenge in contemporary
medicine due to the proliferation of numerous bacterial strains resistant to all existing …

Riboswitches are noncoding RNA that regulate gene expression by folding into specific
three-dimensional structures (holo-form) upon binding by their cognate ligand in the …

During the last decade, riboswitches emerged as new small‐molecule sensing RNA in
bacteria. Thiamine pyrophosphate (TPP) riboswitch is widely distributed and occurs in …

The thiamine pyrophosphate (TPP)-sensing riboswitch is one of the earliest discovered and
most widespread riboswitches. Numerous structural studies have been reported for this …

RNA, a highly charged biopolymer composed of negatively charged phosphate groups,
defies electrostatic repulsion to adopt well-defined, compact structures. Hence, the presence …

Riboswitches are metabolite sensing aptamer domains present in non-coding regions in
RNA and act as gene-regulating elements. Thiamine pyrophosphate (TPP) riboswitch is …

Guanidinium ion is a toxic cellular metabolite. The ykkC-III riboswitch, an mRNA stretch,
regulates the gene expression by undergoing a conformational change in response to the …

Thiamine (vitamin B1) is an essential molecule for all living organisms. It is the precursor for
several phosphorylated derivatives, the most important being the coenzyme thiamine …

Riboswitches are RNA sensors affecting post-transcriptional processes through their ability
to bind to small molecules. Thiamine pyrophosphate (TPP) riboswitch plays a crucial role in …