Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …

Helping B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …

Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is
ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed …

Follicular helper T (TFH) cells provide help to B cells, supporting the formation of germinal
centres that allow affinity maturation of antibody responses. Although usually located in …

Foxp3‐expressing regulatory T (Treg) cells, which are indispensable for preventing
autoimmunity, also suppress effective tumor immunity. Treg cells abundantly infiltrate into …

Regulatory T (Treg) cells expressing the transcription factor Foxp3 have a critical role in the
maintenance of immune homeostasis and prevention of autoimmunity. Recent advances in …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

IL-2 was first identified as a growth factor capable of driving the expansion of activated
human T cell populations. In the more than 40 years since its discovery, a tremendous …

The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid
tissues, producing long-lived antibody secreting plasma cells and memory B cells, which …

Regulatory T cells prevent the emergence of autoantibodies and excessive IgE, but the
precise mechanisms are unclear. Here, we show that BCL6-expressing Tregs, known as …