DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …

Bone morphogenetic protein-2 (BMP-2) is a potent growth factor affecting bone formation.
While recombinant human BMP-2 (rhBMP-2) has been commercially available in cases of …

Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progressive
destruction of articular cartilage. The etiology of OA is complex and involves a variety of …

Background: Autologous fat grafting is a dynamic modality used in plastic surgery as an
adjunct to improve functional and aesthetic form. However, current practices in fat grafting for …

The maintenance of human skeletal stem cells (hSSCs) and their progeny in bone defects is
a major challenge. Here, we report on a transplantable bandage containing a three …

Hydrogels provide a regenerative medicine platform with their ability to create an
environment that supports transplanted or endogenous infiltrating cells and enables these …

Aberrant lineage commitment of mesenchymal stem cells (MSCs) in marrow contributes to
abnormal bone formation due to reduced osteogenic and increased adipogenic potency …

Abstract Purpose of Review The purpose of this review is to discuss the recent advances in
gene therapy as a treatment for bone regeneration. While most fractures heal …

Osteochondral defects involve both the articular cartilage and the underlying subchondral
bone. If left untreated, they may lead to osteoarthritis. Advanced biomaterial-guided delivery …

Background Whilst traditional strategies to increase transfection efficiency of non-viral
systems aimed at modifying the vector or the polyplexes/lipoplexes, biomaterial-mediated …