Multiple strategies to develop small molecular KRAS directly bound inhibitors
X Zhou, Y Ji, J Zhou - Molecules, 2023 - mdpi.com
KRAS gene mutation is widespread in tumors and plays an important role in various
malignancies. Targeting KRAS mutations is regarded as the “holy grail” of targeted cancer …
malignancies. Targeting KRAS mutations is regarded as the “holy grail” of targeted cancer …
[HTML][HTML] Protein post-translational modifications: A key factor in colorectal cancer resistance mechanisms
B Bi, M Qiu, P Liu, Q Wang, Y Wen, Y Li, B Li… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Colorectal cancer (CRC) is one of the leading causes of cancer-related death. Despite
advances in treatment, drug resistance remains a critical impediment. Post-translational …
advances in treatment, drug resistance remains a critical impediment. Post-translational …
Small-molecule RAS inhibitors as anticancer agents: discovery, development, and mechanistic studies
SA Shetu, D Bandyopadhyay - International Journal of Molecular …, 2022 - mdpi.com
Mutations of RAS oncogenes are responsible for about 30% of all human cancer types,
including pancreatic, lung, and colorectal cancers. While KRAS1 is a pseudogene, mutation …
including pancreatic, lung, and colorectal cancers. While KRAS1 is a pseudogene, mutation …
The Clinical Implications of KRAS Mutations and Variant Allele Frequencies in Pancreatic Ductal Adenocarcinoma
F Nusrat, A Khanna, A Jain, W Jiang, H Lavu… - Journal of Clinical …, 2024 - mdpi.com
The KRAS proto-oncogene is a major driver of pancreatic tumorigenesis and is nearly
ubiquitously mutated in pancreatic ductal adenocarcinoma (PDAC). KRAS point mutations …
ubiquitously mutated in pancreatic ductal adenocarcinoma (PDAC). KRAS point mutations …
A small molecule promoting neural differentiation suppresses cancer stem cells in colorectal cancer
JK Choi, IS Kwak, SB Yoon, H Cho, BS Moon - Biomedicines, 2022 - mdpi.com
Cancer stem cells (CSCs) are a tumor cell subpopulation that drives tumor progression and
metastasis, leading to a poor overall survival of patients. In colorectal cancer (CRC), the …
metastasis, leading to a poor overall survival of patients. In colorectal cancer (CRC), the …
A destabilizer of both Wnt/β-catenin and Ras/ERK pathways suppresses cancer stem cell activation in colorectal cancer
JK Choi, IS Kwak, SB Yoon, H Cho, BS Moon - 2022 - preprints.org
Cancer stem cells (CSCs) are a tumor cell subpopulation that drives tumor progression and
metastasis, leading to poor overall survival of patients. In colorectal cancer (CRC), hyper …
metastasis, leading to poor overall survival of patients. In colorectal cancer (CRC), hyper …