Polymyalgia rheumatica

G Espígol-Frigolé, C Dejaco, SL Mackie, C Salvarani… - The Lancet, 2023 - thelancet.com
Polymyalgia rheumatica is an inflammatory disease producing pain and stiffness, mainly in
the shoulders and pelvic girdle, in people older than 50 years. Elevation of acute phase …

The pathophysiology of polymyalgia rheumatica, small pieces of a big puzzle

GC Alegria, S Boukhlal, D Cornec… - Autoimmunity …, 2020 - Elsevier
Polymyalgia rheumatica (PMR) is a frequent rheumatic condition among people over 50
years of age. Despite its frequent association with giant cell arteritis (GCA), PMR can be …

Effect of tocilizumab on disease activity in patients with active polymyalgia rheumatica receiving glucocorticoid therapy: a randomized clinical trial

V Devauchelle-Pensec, G Carvajal-Alegria, E Dernis… - Jama, 2022 - jamanetwork.com
Importance Few treatments are available for patients with glucocorticoid-dependent
polymyalgia rheumatica. IL-6 antagonists may reduce disease activity in patients with active …

Update on the epidemiology, risk factors, and outcomes of systemic vasculitides

A Berti, C Dejaco - Best practice & research Clinical rheumatology, 2018 - Elsevier
Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) and giant cell
arteritis (GCA) are the most common primary systemic vasculitides of the adult population …

Biological therapy in polymyalgia rheumatica

D Wendling - Expert Opinion on Biological Therapy, 2023 - Taylor & Francis
Introduction Polymyalgia rheumatica (PMR) is an inflammatory rheumatic disease of the
elderly, treated mainly with systemic corticosteroids. The frequency of side effects of steroids …

Efficacy and management of tocilizumab in polymyalgia rheumatica: results of a multicentre retrospective observational study

M Assaraf, B Chevet, D Wendling, P Philippe… - …, 2023 - academic.oup.com
Objectives The efficacy of anti-IL-6 receptors such as tocilizumab (TCZ) was demonstrated in
patients with PMR in two recent randomized controlled trials. The objective of this …

Polymyalgia rheumatica with normal values of both erythrocyte sedimentation rate and C-reactive protein concentration at the time of diagnosis

C Manzo, M Milchert, M Natale, M Brzosko - Rheumatology, 2019 - academic.oup.com
SIR, Bilateral shoulder and hip pain, often accompanied with neck aching, and morning
stiffness lasting> 45 min are typical manifestations of PMR. In many cases, the patient …

Biomarkers in the era of targeted therapy in giant cell arteritis and polymyalgia rheumatica: is it possible to replace acute-phase reactants?

G Carvajal Alegria, M Nicolas, Y van Sleen - Frontiers in Immunology, 2023 - frontiersin.org
Research into giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) has become
more important in the last few decades. Physicians are facing several challenges in …

Measurement properties of the polymyalgia rheumatica activity score: a systematic literature review

TE Bolhuis, LEA Nizet, C Owen… - The Journal of …, 2022 - jrheum.org
Objective. To perform a COnsensus-based Standards for the selection of health
Measurement INstruments (COSMIN)-based systematic literature review of measurement …

Concordance and agreement between different activity scores in polymyalgia rheumatica

J D'Agostino, A Souki, A Lohse, GC Alegria… - RMD open, 2024 - rmdopen.bmj.com
Objective The C reactive protein polymyalgia rheumatica activity score (CRP-PMR-AS) is a
composite index that includes CRP levels and was developed specifically for PMR. As …