As the professional antigen-presenting cells of the immune system, dendritic cells (DCs)
sense the microenvironment and shape the ensuing adaptive immune response. DCs can …

Subunit vaccines are more advantageous than live attenuated vaccines in terms of safety
and scale-up manufacture. However, this often comes as a trade-off to their efficacy. Over …

The need to optimize vaccine potency while minimizing toxicity in healthy recipients has
motivated studies of the formulation of vaccines to control how, when, and where antigens …

Virus-like particles (VLPs) have been shown to be strong activators of dendritic cells (DCs).
DCs are the most potent antigen presenting cells (APCs) and their activation prompts the …

T cells are critical in orchestrating protective immune responses to cancer and an array of
pathogens. The interaction between a peptide MHC (pMHC) complex on antigen presenting …

Breast cancer (BC) is known to be a highly heterogeneous disease that is clinically
subdivided into four primary molecular subtypes, each having distinct morphology and …

Although there has been major recent progress in malaria vaccine development, substantial
challenges remain for achieving highly efficacious and durable vaccines against …

CircRNAs are a class of single-stranded RNAs with covalently linked head-to-tail topology.
In the decades since its initial discovery, their biogenesis, regulation, and function have …

T follicular helper (Tfh) cells are a specialized subset of CD4+ T cells that collaborate with B
cells to promote and regulate humoral responses. Unlike other CD4+ effector lineages, Tfh …

CD4+ follicular helper T (Tfh) cells constitute a subset of effector T cells that participate in the
generation of high-affinity humoral responses. They express the chemokine receptor …