The recently discovered functions of RNA dramatically expand the cellular roles for this
macromolecule. RNA can no longer be viewed as a passive element, working simply as an …

Progressive supranuclear palsy is a sporadic and progressive neurodegenerative disease,
most often presenting as a symmetric, akinetic-rigid syndrome with postural instability …

Myotonic dystrophy type 1 (DM1), the most common form of muscular dystrophy in adults, is
an RNA-mediated disease. Dramatically expanded (CUG) repeats accumulate in nuclei and …

Herein is described the identification of RNA internal loops that bind to derivatives of
neomycin B, neamine, tobramycin, and kanamycin A. RNA loop− ligand partners were …

Despite their inherent toxicity and the acquired bacterial resistance that continuously
threaten their long-term clinical use, aminoglycosides (AGs) still remain valuable …

Herein, we report the development of a microarray platform to select RNA motif− ligand
interactions that allows simultaneous screening of both RNA and chemical space. We used …

Bacterial ribosomal RNA is the target of clinically important antibiotics, while biologically
important RNAs in viral and eukaryotic genomes present a range of potential drug targets …

The implication of RNA in multiple cellular processes beyond protein coding has revitalized
interest in the development of small molecules for therapeutically targeting RNA and for …

In recent years, several high-resolution structures of aptamer complexes have shed light on
the binding mode and recognition principles of aptamer complexe interactions. In some …

A new family of G-quadruplex ligands termed “amido phthalocyanines”(APcs) was
synthesized by reacting variable amino acids with tetraamino zinc phthalocyanine. Variation …