Warfarin is a widely used anticoagulant with a narrow therapeutic index and large
interpatient variability in the dose required to achieve target anticoagulation. Common …

Vascular mineralization has recently emerged as a risk factor for cardiovascular morbidity
and mortality. Previously regarded as a passive end-stage process, vascular mineralization …

The article discusses the guidelines of the United Kingdom Haemophilia Centre Doctors'
Organization (UKHCDO) related to the diagnosis and management of patients with rare …

Purpose RAF inhibitors are effective against melanomas with BRAF V600E mutations but
may induce keratoacanthomas (KAs) and cutaneous squamous cell carcinomas (cSCCs) …

Pseudoxanthoma elasticum (PXE) is a genetic metabolic disease with autosomal recessive
inheritance caused by mutations in the ABCC6 gene. The lack of functional ABCC6 protein …

Spontaneous pathologic arterial calcifications in childhood can occur in generalized arterial
calcification of infancy (GACI) or in pseudoxanthoma elasticum (PXE). GACI is associated …

Among the proteins involved in vascular calcium metabolism, the vitamin K-dependent
matrix Gla-protein (MGP) plays a dominant role. Although on a molecular level its …

Vascular disease is still the leading cause of morbidity and mortality in the Western world,
and the primary cause of myocardial infarction, stroke, and ischemia. The biology of vascular …

Cutis laxa is a rare disorder of elastic tissue resulting in loose, redundant, hypoelastic skin.
Both acquired and inherited forms exist, some of which have significant systemic …

Vitamin K‐dependent proteins require carboxylation of certain glutamates for their biological
functions. The enzymes involved in the vitamin K‐dependent carboxylation include: gamma …