The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar
disorder (BD), a severe mental illness arising from complex interactions between genes and …

Histone acetylation is a critical epigenetic modification that changes chromatin architecture
and regulates gene expression by opening or closing the chromatin structure. It plays an …

Novel treatment regimens are required for castration-resistant prostate cancers (CRPCs)
that become unresponsive to standard treatments, such as docetaxel and enzalutamide …

Multi-cellular spheroids mimic the complex three-dimensional environment of natural
tissues. Accordingly, they are also used as vascularization units in angiogenesis research …

Diabetes mellitus (DM) is one of the principal manifestations of metabolic syndrome and its
prevalence with modern lifestyle is increasing incessantly. Chronic hyperglycemia can …

Background and Purpose—Enhanced angiogenesis facilitates neurovascular remodeling
processes and promotes brain functional recovery after stroke. Previous studies from our …

Ischemic stroke is a leading cause of death and disability worldwide, with few available
treatment options. The pathophysiology of cerebral ischemia involves both early phase …

Atherosclerosis (AS), the most common underlying pathology for coronary artery disease, is
a chronic inflammatory, proliferative disease in large-and medium-sized arteries. The …

Endothelial cell (EC), consisting of the innermost cellular layer of all types of vessels, is not
only a barrier composer but also performing multiple functions in physiological processes. It …

Pharmacological modulation of class I histone deacetylases (HDAC) has been evaluated as
a therapeutic strategy for pulmonary hypertension (PH) in experimental models of PH …