Antidepressant and anxiolytic effects of activating 5HT2A receptors in the anterior cingulate cortex and the theoretical mechanisms underlying them–A scoping review …
L Miranda - Brain Research, 2024 - Elsevier
Psychedelic drugs that activate the 5HT2A receptor have long been the target of extensive
clinical research, particularly in models of psychiatric illness. The aim of this literature review …
clinical research, particularly in models of psychiatric illness. The aim of this literature review …
How can neurobiology of fear extinction inform treatment?
The neurobiology of extinction learning has been translated to inform the delivery of
exposure therapy, the gold-standard treatment for fear and anxiety disorders. The inhibitory …
exposure therapy, the gold-standard treatment for fear and anxiety disorders. The inhibitory …
Temporally and anatomically specific contributions of the human amygdala to threat and safety learning
Z Wen, CM Raio, EF Pace-Schott… - Proceedings of the …, 2022 - National Acad Sciences
Neural plasticity in subareas of the rodent amygdala is widely known to be essential for
Pavlovian threat conditioning and safety learning. However, less consistent results have …
Pavlovian threat conditioning and safety learning. However, less consistent results have …
The amygdala and depression: A sober reconsideration
SE Grogans, AS Fox… - American Journal of …, 2022 - Am Psychiatric Assoc
Depressive disorders are a leading cause of global disability, afflicting approximately 280
million individuals worldwide each year (1). In the United States, more than one in five …
million individuals worldwide each year (1). In the United States, more than one in five …
Using what we know about threat reactivity models to understand mental health during the COVID-19 pandemic
CJ Funkhouser, DM Klemballa… - Behaviour Research and …, 2022 - Elsevier
The COVID-19 pandemic has been accompanied by unprecedented levels of stress and
threats in a variety of domains (eg, health, livelihood). Individual differences in threat …
threats in a variety of domains (eg, health, livelihood). Individual differences in threat …
From neural circuits to communities: an integrative multidisciplinary roadmap for global mental health
Suffering due to mental health problems is rising inexorably in all regions of the world. One
major reason is that our understanding of the causation, prevention and treatment of mental …
major reason is that our understanding of the causation, prevention and treatment of mental …
[HTML][HTML] Association between reward-related functional connectivity and tri-level mood and anxiety symptoms
Depression and anxiety are associated with abnormalities in brain regions that process
rewards including the medial orbitofrontal cortex (mOFC), the ventral striatum (VS), and the …
rewards including the medial orbitofrontal cortex (mOFC), the ventral striatum (VS), and the …
Neural sensitivity following stress predicts anhedonia symptoms: a 2-year multi-wave, longitudinal study
Animal models of depression show that acute stress negatively impacts functioning in neural
regions sensitive to reward and punishment, often manifesting as anhedonic behaviors …
regions sensitive to reward and punishment, often manifesting as anhedonic behaviors …
No joy-why bother? Higher anhedonia relates to reduced pleasure from and motivation for threat avoidance
Anhedonia impairs various components of the pleasure cycle, including wanting, liking, and
the learning of pleasure-related associations. While successfully controlling threats might be …
the learning of pleasure-related associations. While successfully controlling threats might be …
Integrating threat conditioning and the hierarchical taxonomy of psychopathology to advance the study of anxiety-related psychopathology.
Theoretical and methodological research on threat conditioning provides important
neuroscience-informed approaches to studying fear and anxiety. The threat conditioning …
neuroscience-informed approaches to studying fear and anxiety. The threat conditioning …