Natural killer (NK) cells are innate immune cells that show strong cytolytic function against
physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a …

After a century of controversy, the notion that the immune system regulates cancer
development is experiencing a new resurgence. An overwhelming amount of data from …

MICA and MICB are expressed by many human cancers as a result of cellular stress, and
can tag cells for elimination by cytotoxic lymphocytes through natural killer group 2D …

The last fifteen years have seen a reemergence of interest in cancer immunosurveillance
and a broadening of this concept into one termed cancer immunoediting. The latter …

According to present concepts, innate immunity is regulated by receptors that determine
danger levels by responding to molecules that are associated with infection or cellular …

Immune checkpoint inhibitors (ICI) revolutionized the field of immuno-oncology and opened
new avenues towards the development of novel assets to achieve durable immune control …

In recent years, mesenchymal stem cells (MSCs) have been shown to inhibit T-lymphocyte
proliferation induced by alloantigens or mitogens. However, no substantial information is …

Human natural killer (NK) cells express a series of activating receptors and coreceptors that
are involved in recognition and killing of target cells. In this study, in an attempt to identify the …

Cancer development is often associated with the lack of specific and efficient recognition of
tumor cells by the immune system. Natural killer (NK) cells are lymphocytes of the innate …

Cellular transformation and tumor development result from an accumulation of mutational
and epigenetic changes that alter normal cell growth and survival pathways. For the last 100 …