A validation of models for prediction of pathogenic variants in mismatch repair genes

C Shyr, AL Blackford, T Huang, J Ke, N Ouardaoui… - Genetics in …, 2022 - Elsevier
Purpose Models used to predict the probability of an individual having a pathogenic
homozygous or heterozygous variant in a mismatch repair gene, such as MMRpro, are …

Combining breast cancer risk prediction models

Z Guan, T Huang, AM McCarthy, K Hughes, A Semine… - Cancers, 2023 - mdpi.com
Simple Summary BRCAPRO is a widely used breast cancer risk prediction model based on
family history. A major limitation of this model is that it does not consider non-genetic risk …

Innovative Approaches for Risk Assessment in Panel Gene Testing

JW Liang - 2022 - search.proquest.com
Panel germline tests simultaneously detect multiple pathogenic variants, typically grouped
by association with a higher risk of developing certain cancers or syndromes. Next …