Native mass spectrometry: recent progress and remaining challenges
Native mass spectrometry (nMS) has emerged as an important tool in studying the structure
and function of macromolecules and their complexes in the gas phase. In this review, we …
and function of macromolecules and their complexes in the gas phase. In this review, we …
Towards higher sensitivity of mass spectrometry: a perspective from the mass analyzers
C Li, S Chu, S Tan, X Yin, Y Jiang, X Dai… - Frontiers in …, 2021 - frontiersin.org
Mass spectrometry (MS) is one of the most widely used analytical techniques in many fields.
Recent developments in chemical and biological researches have drawn much attention to …
Recent developments in chemical and biological researches have drawn much attention to …
Trapped ion mobility spectrometry and parallel accumulation–serial fragmentation in proteomics
Recent advances in efficiency and ease of implementation have rekindled interest in ion
mobility spectrometry, a technique that separates gas phase ions by their size and shape …
mobility spectrometry, a technique that separates gas phase ions by their size and shape …
[HTML][HTML] MALDI HiPLEX-IHC: multiomic and multimodal imaging of targeted intact proteins in tissues
Matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is one
of the most widely used methods for imaging the spatial distribution of unlabeled small …
of the most widely used methods for imaging the spatial distribution of unlabeled small …
Structure and dynamics of endogenous cardiac troponin complex in human heart tissue captured by native nanoproteomics
Protein complexes are highly dynamic entities that display substantial diversity in their
assembly, post-translational modifications, and non-covalent interactions, allowing them to …
assembly, post-translational modifications, and non-covalent interactions, allowing them to …
Ion mobility mass spectrometry for the separation and characterization of small molecules
Small molecules with molecular weights less than 1500 Da represented by natural
metabolites such as amino acids, nucleotides, carbohydrates, lipids, flavonoids, alkaloids …
metabolites such as amino acids, nucleotides, carbohydrates, lipids, flavonoids, alkaloids …
High-throughput multi-attribute analysis of antibody-drug conjugates enabled by trapped ion mobility spectrometry and top-down mass spectrometry
EJ Larson, DS Roberts, JA Melby, KM Buck… - Analytical …, 2021 - ACS Publications
Antibody-drug conjugates (ADCs) are one of the fastest growing classes of anticancer
therapies. Combining the high targeting specificity of monoclonal antibodies (mAbs) with …
therapies. Combining the high targeting specificity of monoclonal antibodies (mAbs) with …
Structural O-glycoform heterogeneity of the SARS-CoV-2 spike protein receptor-binding domain revealed by top-down mass spectrometry
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes an extensively
glycosylated surface spike (S) protein to mediate host cell entry, and the S protein …
glycosylated surface spike (S) protein to mediate host cell entry, and the S protein …
Tandem-trapped ion mobility spectrometry/mass spectrometry (t TIMS/MS): a promising analytical method for investigating heterogenous samples
Ion mobility spectrometry/mass spectrometry (IMS/MS) is widely used to study various levels
of protein structure. Here, we review the current state of affairs in tandem-trapped ion …
of protein structure. Here, we review the current state of affairs in tandem-trapped ion …
Advances in high‐resolution mass spectrometry techniques for analysis of high mass‐to‐charge ions
YH Lai, YS Wang - Mass Spectrometry Reviews, 2023 - Wiley Online Library
A major challenge in modern mass spectrometry (MS) is achieving high mass resolving
power and accuracy for precision analyses in high mass‐to‐charge (m/z) regions. To …
power and accuracy for precision analyses in high mass‐to‐charge (m/z) regions. To …