The tumor microenvironment: a milieu hindering and obstructing antitumor immune responses

A Labani-Motlagh, M Ashja-Mahdavi… - Frontiers in …, 2020 - frontiersin.org
The success of cancer immunotherapy relies on the knowledge of the tumor
microenvironment and the immune evasion mechanisms in which the tumor, stroma, and …

The regulatory function of eosinophils

T Wen, ME Rothenberg - Microbiology spectrum, 2016 - Am Soc Microbiol
Eosinophils are a minority circulating granulocyte classically viewed as being involved in
host defense against parasites and promoting allergic reactions. However, a series of new …

Eosinophils in filarial infections: Inducers of protection or pathology?

A Ehrens, A Hoerauf, MP Hübner - Frontiers in Immunology, 2022 - frontiersin.org
Filariae are parasitic roundworms, which can cause debilitating diseases such as lymphatic
filariasis and onchocerciasis. Lymphatic filariasis, also known as elephantiasis, and …

The role of helminths in the development of non-communicable diseases

Y Wu, M Duffey, SE Alex, C Suarez-Reyes… - Frontiers in …, 2022 - frontiersin.org
Non-communicable diseases (NCDs) like cardiovascular disease, chronic respiratory
diseases, cancers, diabetes, and neuropsychiatric diseases cause significant global …

Prenatal immune priming with helminth infections: parasite‐specific cellular reactivity and Th1 and Th2 cytokine responses in neonates

DSS Pit, AM Polderman, H Schulz‐Key, PT Soboslay - Allergy, 2000 - Wiley Online Library
The present investigation aimed to determine to what extent maternal helminth infection
primes parasite‐specific cellular responsiveness in neonates. Umbilical cord mononuclear …

Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner

B Lenz, A Ehrens, J Ajendra, F Risch, J Gal… - PLoS …, 2024 - journals.plos.org
Background Eosinophilia is a hallmark of helminth infections and eosinophils are essential
in the protective immune responses against helminths. Nevertheless, the distinct role of …

Impact of surfactant protein D, interleukin-5, and eosinophilia on Cryptococcosis

SM Holmer, KS Evans, YG Asfaw, D Saini… - Infection and …, 2014 - Am Soc Microbiol
Cryptococcus neoformans is an opportunistic fungal pathogen that initiates infection
following inhalation. As a result, the pulmonary immune response provides a first line of …

Wolbachia-Induced Neutrophil Activation in a Mouse Model of Ocular Onchocerciasis (River Blindness)

I Gillette-Ferguson, AG Hise, HF McGarry… - Infection and …, 2004 - Am Soc Microbiol
Endosymbiotic Wolbachia bacteria are abundant in the filarial nematodes that cause
onchocerciasis (river blindness), including the larvae (microfilariae) that migrate into the …

IL-4 receptor dependent expansion of lung CD169+ macrophages in microfilaria-driven inflammation

F Fercoq, E Remion, SJ Frohberger… - PLoS neglected …, 2019 - journals.plos.org
Lung disease is regularly reported in human filarial infections but the molecular
pathogenesis of pulmonary filariasis is poorly understood. We used Litomosoides …

Histopathological analysis of initial cellular response in TLR‐2 deficient mice experimentally infected by Leishmania (L.) amazonensis

CS Guerra, RM Macedo Silva… - International journal …, 2010 - Wiley Online Library
Tegumentary leishmaniasis is an important public health problem in several countries. The
capacity of the Leishmania species, at the initial moments of the infection, to invade and …