[HTML][HTML] Leptin hormone and its effectiveness in reproduction, metabolism, immunity, diabetes, hopes and ambitions

HA Al-Hussaniy, AH Alburghaif… - Journal of Medicine and …, 2021 - ncbi.nlm.nih.gov
Leptin is a hormone derived from adipose tissue and the small intestine, mainly in
enterocytes; it helps regulate the energy balance by suppressing hunger, resulting in …

The emerging therapeutic potential of kisspeptin and neurokinin B

B Patel, K Koysombat, EG Mills, J Tsoutsouki… - Endocrine …, 2024 - academic.oup.com
Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive
endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) …

Recent advances in emerging PCOS therapies

KA Glendining, RE Campbell - Current Opinion in Pharmacology, 2023 - Elsevier
Polycystic ovary syndrome is a prevalent endocrinopathy involving androgen excess, and
anovulatory infertility. The disorder is also associated with many comorbidities such as …

Treatments targeting neuroendocrine dysfunction in polycystic ovary syndrome (PCOS)

A Garg, B Patel, A Abbara, WS Dhillo - Clinical endocrinology, 2022 - Wiley Online Library
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of
reproductive age and is the leading cause of anovulatory subfertility. Increased …

[HTML][HTML] Polycystic ovary syndrome: pathophysiology and therapeutic opportunities

J Dong, DA Rees - BMJ medicine, 2023 - ncbi.nlm.nih.gov
Polycystic ovary syndrome is characterised by excessive levels of androgens and ovulatory
dysfunction, and is a common endocrine disorder in women of reproductive age. Polycystic …

Polycystic ovarian syndrome: Current scenario and future insights

S Kulkarni, K Gupta, P Ratre, PK Mishra, Y Singh… - Drug Discovery …, 2023 - Elsevier
Polycystic ovarian syndrome (PCOS) prevails in approximately 33% of females of
reproductive age globally. Although the root cause of the disease is unknown, attempts are …

Overactivation of GnRH neurons is sufficient to trigger polycystic ovary syndrome-like traits in female mice

MSB Silva, L Decoster, G Delpouve, T Lhomme… - …, 2023 - thelancet.com
Background Polycystic ovary syndrome (PCOS) is the most common endocrine disorder
leading to anovulatory infertility. Abnormalities in the central neuroendocrine system …

Hypothalamic neurokinin signalling and its application in reproductive medicine

K Skorupskaite, RA Anderson - Pharmacology & Therapeutics, 2022 - Elsevier
The discovery of the essential requirement for kisspeptin and subsequently neurokinin B
signalling for human reproductive function has sparked renewed interest in the …

Chronic androgen excess in female mice does not impact luteinizing hormone pulse frequency or putative GABAergic inputs to GnRH neurons

CS Coyle, M Prescott, DJ Handelsman… - Journal of …, 2022 - Wiley Online Library
Polycystic ovary syndrome (PCOS) is associated with androgen excess and, frequently,
hyperactive pulsatile luteinizing hormone (LH) secretion. Although the origins of PCOS are …

Key signalling pathways underlying the aetiology of polycystic ovary syndrome

KA Walters, A Moreno-Asso, NK Stepto… - Journal of …, 2022 - joe.bioscientifica.com
Polycystic ovary syndrome (PCOS) is a common endocrine condition characterised by a
range of reproductive, endocrine, metabolic and psychological abnormalities. Reports …