Pathophysiology and treatment of stroke: present status and future perspectives

D Kuriakose, Z Xiao - International journal of molecular sciences, 2020 - mdpi.com
Stroke is the second leading cause of death and a major contributor to disability worldwide.
The prevalence of stroke is highest in developing countries, with ischemic stroke being the …

Therapeutic potential of neurotrophins for repair after brain injury: a helping hand from biomaterials

J Houlton, N Abumaria, SFR Hinkley… - Frontiers in …, 2019 - frontiersin.org
Stroke remains the leading cause of long-term disability with limited options available to aid
in recovery. Significant effort has been made to try and minimize neuronal damage following …

Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic immunosuppression

TR Doeppner, J Herz, A Görgens… - Stem cells …, 2015 - academic.oup.com
Although the initial concepts of stem cell therapy aimed at replacing lost tissue, more recent
evidence has suggested that stem and progenitor cells alike promote postischemic …

Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models

L Bai, DP Lennon, AI Caplan, A DeChant… - Nature …, 2012 - nature.com
Mesenchymal stem cells (MSCs) have emerged as a potential therapy for a range of neural
insults. In animal models of multiple sclerosis, an autoimmune disease that targets …

Neurogenesis in stroke recovery

SH Koh, HH Park - Translational stroke research, 2017 - Springer
Stroke, resulting from limited blood flow to the brain, is one of the most important causes of
morbidity and mortality worldwide. Stroke is classified as ischemic, due to lack of blood flow …

Effects of intravenous administration of allogenic bone marrow-and adipose tissue-derived mesenchymal stem cells on functional recovery and brain repair markers in …

M Gutiérrez-Fernández, B Rodríguez-Frutos… - Stem cell research & …, 2013 - Springer
Introduction Stem cell therapy can promote good recovery from stroke. Several studies have
demonstrated that mesenchymal stem cells (MSC) are safe and effective. However, more …

Mesenchymal stem cell treatment after neonatal hypoxic-ischemic brain injury improves behavioral outcome and induces neuronal and oligodendrocyte regeneration

CTJ van Velthoven, A Kavelaars, F van Bel… - Brain, behavior, and …, 2010 - Elsevier
Birth asphyxia is a frequent cause of perinatal morbidity and mortality and treatment options
are very limited. Our aim was to determine the effects of treatment with bone marrow-derived …

Cerebral ischemia and neuroregeneration

RHC Lee, MHH Lee, CYC Wu, AC e Silva… - Neural regeneration …, 2018 - journals.lww.com
Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide.
Although stroke (a form of cerebral ischemia)-related costs are expected to reach 240.67 …

Exosomes derived from bone marrow mesenchymal stem cells harvested from type two diabetes rats promotes neurorestorative effects after stroke in type two …

P Venkat, A Zacharek, J Landschoot-Ward… - Experimental …, 2020 - Elsevier
Background and purpose Diabetes elevates the risk of stroke, promotes inflammation, and
exacerbates vascular and white matter damage post stroke, thereby hindering long term …

Human umbilical mesenchymal stem cells promote recovery after ischemic stroke

YC Lin, TL Ko, YH Shih, MYA Lin, TW Fu, HS Hsiao… - Stroke, 2011 - Am Heart Assoc
Background and Purpose—Stroke is a cerebrovascular defect that leads to many adverse
neurological complications. Current pharmacological treatments for stroke remain unclear in …