Investigation of macromolecular structure and dynamics is fundamental to understanding
how macromolecules carry out their functions in the cell. Significant advances have been …

The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. This talk will provide
an overview of new approaches to study and manipulate signaling in living cells and …

The evolutionary trajectory of a protein through sequence space is constrained by its
function. Collections of sequence homologs record the outcomes of millions of evolutionary …

Protein secondary structure prediction began in 1951 when Pauling and Corey predicted
helical and sheet conformations for protein polypeptide backbone even before the first …

Oligomers of amyloid β-protein (Aβ) play a central role in the pathology of Alzheimer's
disease. Of the two predominant Aβ alloforms, Aβ1− 40 and Aβ1− 42, Aβ1− 42 is more …

Human Vγ9Vδ2 T cells are well known for their rapid and potent response to infection and
tumorigenesis when in the presence of endogenous or exogenous phosphoisoprenoids …

Compared to the protein 3-class secondary structure (SS) prediction, the 8-class prediction
gains less attention and is also much more challenging, especially for proteins with few …

Local structures predicted from protein sequences are used extensively in every aspect of
modeling and prediction of protein structure and function. For more than 50 years, they have …

Since its introduction, the basin hopping (BH) framework has proven useful for hard
nonlinear optimization problems with multiple variables and modalities. Applications span a …

CD1 molecules function to present lipid-based antigens to T cells. Here we present the
crystal structure of CD1c at 2.5 Å resolution, in complex with the pathogenic Mycobacterium …