Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R)
Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new
series of anticancer agents. Thirty-two new compounds were synthesised where x-ray …
series of anticancer agents. Thirty-two new compounds were synthesised where x-ray …
Synthesis of new multitarget-directed ligands containing thienopyrimidine nucleus for inhibition of 15-lipoxygenase, cyclooxygenases, and pro-inflammatory cytokines
A new series of thieno [2, 3-d] pyrimidine derivatives 4, 5, 6a-o, and 11 was designed and
synthesized starting from cyclohexanone under Gewald condition with the aim to develop …
synthesized starting from cyclohexanone under Gewald condition with the aim to develop …
Lipoxygenases at the Intersection of Infection and Carcinogenesis
AS Amoah, NB Pestov, TV Korneenko… - International Journal of …, 2024 - mdpi.com
The persisting presence of opportunistic pathogens like Pseudomonas aeruginosa poses a
significant threat to many immunocompromised cancer patients with pulmonary infections …
significant threat to many immunocompromised cancer patients with pulmonary infections …
Tailored quinoline hybrids as promising COX-2/15-LOX dual inhibitors endowed with diverse safety profile: Design, synthesis, SAR, and histopathological study
Complications of the worldwide use of non-steroidal anti-inflammatory drugs (NSAIDs)
sparked scientists to design novel harmless alternatives as an urgent need. So, a unique …
sparked scientists to design novel harmless alternatives as an urgent need. So, a unique …
COX‐2 in lung cancer: Mechanisms, development, and targeted therapies
X Liu, J Zhang, W Sun, J Cao… - Chronic Diseases and …, 2024 - Wiley Online Library
Lung cancer (LC) is the leading cause of cancer‐related death worldwide, with non‐small
cell lung cancer (NSCLC) comprising 85% of all cases. COX‐2, an enzyme induced …
cell lung cancer (NSCLC) comprising 85% of all cases. COX‐2, an enzyme induced …
Design, Synthesis, Biological Evaluation, and Molecular Docking Study of 4, 6-Dimethyl-5-aryl/alkyl-2-[2-hydroxy-3-(4-substituted-1-piperazinyl) propyl] pyrrolo [3, 4-c] …
A Redzicka, B Wiatrak, I Jęśkowiak-Kossakowska… - Pharmaceuticals, 2023 - mdpi.com
In the present study, we characterize the biological activity of a newly designed and
synthesized series of 15 compounds 2-[2-hydroxy-3-(4-substituted-1-piperazinyl) propyl] …
synthesized series of 15 compounds 2-[2-hydroxy-3-(4-substituted-1-piperazinyl) propyl] …
Fatty acid modification of casein bioactive peptides nano-assemblies, synthesis, characterization and anticarcinogenic effect
Y Song, Z Wang, H Ji, Z Jiang, X Li, Z Du, S Wei… - International Journal of …, 2024 - Elsevier
In this study, the nano-assemblies of bovine casein hydrolyzed peptides (HP) modified by
fatty acids with various alkyl chain lengths (C8, C10, C12 and C14) were synthesized. The …
fatty acids with various alkyl chain lengths (C8, C10, C12 and C14) were synthesized. The …
Novel 2‐[thio] acetamide linked quinazoline/1, 2, 4‐triazole/chalcone hybrids: Design, synthesis, and anticancer activity as EGFR inhibitors and apoptotic inducers
Novel triazoloquinazolines carrying the 2‐[thio] acetamide entity (4 and 5a–d) and
triazoloquinazoline/chalcone hybrids incorporating the 2‐[thio] acetamide linker (8a–b and …
triazoloquinazoline/chalcone hybrids incorporating the 2‐[thio] acetamide linker (8a–b and …
PREPARATION, DIAGNOSIS AND EVALUATION OF THE BACTERIAL EFFICACY OF A NEW DERIVATIVE OF THE 2, 3-DIHYDROQUINAZOLINE-4-ONE RING
ZA Murad - EUROPEAN JOURNAL OF MODERN MEDICINE AND …, 2024 - inovatus.es
This research included the preparation of Schiff bases (Z1-Z5 (from the reaction one mole of
(terephthalaldehyde) with two mole of aniline derivatives, and then the preparation of 2, 3 …
(terephthalaldehyde) with two mole of aniline derivatives, and then the preparation of 2, 3 …