Many drug targets are embedded within the phospholipid bilayer of cellular membranes,
including G protein-coupled receptors, ion channels, transporters and membrane-bound …

GABA A receptors are pentameric ligand-gated ion channels that mediate most fast
neuronal inhibition in the brain. In addition to their important physiological roles, they are …

The α7 nicotinic acetylcholine receptor plays critical roles in the central nervous system and
in the cholinergic inflammatory pathway. This ligand-gated ion channel assembles as a …

Abstract γ-Aminobutyric acid type A (GABAA) receptors mediate fast inhibitory signaling in
the brain and are targets of numerous drugs and endogenous neurosteroids. A subset of …

Type A γ-aminobutyric acid receptors (GABAARs) are the principal inhibitory receptors in the
brain and the target of a wide range of clinical agents, including anaesthetics, sedatives …

Abstract γ-Aminobutyric acid type A (GABAA) receptors are pentameric ligand-gated ion
channels abundant in the central nervous system and are prolific drug targets for treating …

Binding of the neurotransmitter acetylcholine to its receptors on muscle fibers depolarizes
the membrane and thereby triggers muscle contraction. We sought to understand at the level …

The molecular mechanisms of coevolution between plants and insects remain elusive.
GABA receptors are targets of many neurotoxic terpenoids, which represent the most diverse …

Pyrimidines are nitrogen-containing heterocycles known for anticancer, anti-HIV, antifungal,
and antibacterial activities. Pyrimidines, compounds bearing this heterocycle, are common …

Autoantibodies targeting neuronal membrane proteins can cause encephalitis, seizures,
and severe behavioral abnormalities. While antibodies for several neuronal targets have …