The rising emergence of antibiotic resistance urges the search for new strategies to defeat
microorganisms that lead to persistent infections of the host. Tolerant to antibiotics, slowly …

Antibiotics are the cornerstone of modern medicine and agriculture, and rising antibiotic
resistance is one the biggest threats to global health and food security. Identifying new and …

The last step of cysteine biosynthesis in bacteria and plants is catalyzed by O-acetylserine
sulfhydrylase. In bacteria, two isozymes, O-acetylserine sulfhydrylase-A and O-acetylserine …

The cysteine biosynthetic pathway is absent in humans but essential in microbial pathogens,
suggesting that it provides potential targets for the development of novel antibacterial …

Background Dengue has emerged as the most significant of arboviral diseases in the 21st
century. It is endemic to> 100 tropical and sub-tropical countries around the world placing an …

The principal mechanism of reducing sulfur into organic compounds is via the synthesis of l-
cysteine. Cysteine is used for protein and glutathione synthesis, as well as being the primary …

Cysteine is a building block for several biomolecules that are crucial for living organisms.
The last step of cysteine biosynthesis is catalyzed by O-acetylserine sulfydrylase (OASS), a …

The alarming increase of drug resistance in Mycobacterium tuberculosis strains poses a
severe threat to human health. Chemotherapy is particularly challenging because M …

Owing to the global health crisis of resistant pathogenic infections, researchers are
emphasizing the importance of novel prevention and control strategies. Existing …

Novel hybrid molecules of thiazolopyrimidine 4a–j have been prepared starting from various
thiazoles 3a–j. The reaction of thiazoles 3a–j with thiourea yielded hybrid molecules 4a–j in …