RNA-binding proteins balance brain function in health and disease

R Schieweck, J Ninkovic… - Physiological reviews, 2021 - journals.physiology.org
Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …

Splicing-factor alterations in cancers

O Anczuków, AR Krainer - Rna, 2016 - rnajournal.cshlp.org
Tumor-associated alterations in RNA splicing result either from mutations in splicing-
regulatory elements or changes in components of the splicing machinery. This review …

Green light analgesia in mice is mediated by visual activation of enkephalinergic neurons in the ventrolateral geniculate nucleus

YL Tang, AL Liu, SS Lv, ZR Zhou, H Cao… - Science Translational …, 2022 - science.org
Green light exposure has been shown to reduce pain in animal models. Here, we report a
vision-associated enkephalinergic neural circuit responsible for green light–mediated …

Translating neural stem cells to neurons in the mammalian brain

SK Zahr, DR Kaplan, FD Miller - Cell Death & Differentiation, 2019 - nature.com
The mammalian neocortex underlies our perception of sensory information, performance of
motor activities, and higher-order cognition. During mammalian embryogenesis, radial glial …

Poison exon splicing regulates a coordinated network of SR protein expression during differentiation and tumorigenesis

NK Leclair, M Brugiolo, L Urbanski, SC Lawson… - Molecular Cell, 2020 - cell.com
The RNA isoform repertoire is regulated by splicing factor (SF) expression, and alterations in
SF levels are associated with disease. SFs contain ultraconserved poison exon (PE) …

Genomics of alternative splicing: evolution, development and pathophysiology

ER Gamazon, BE Stranger - Human genetics, 2014 - Springer
Alternative splicing is a major cellular mechanism in metazoans for generating proteomic
diversity. A large proportion of protein-coding genes in multicellular organisms undergo …

RNA on the brain: emerging layers of post‐transcriptional regulation in cerebral cortex development

AL Lennox, H Mao, DL Silver - Wiley Interdisciplinary Reviews …, 2018 - Wiley Online Library
Embryonic development is a critical period during which neurons of the brain are generated
and organized. In the developing cerebral cortex, this requires complex processes of neural …

Post‐transcriptional regulation in corticogenesis: how RNA‐binding proteins help build the brain

LJ Pilaz, DL Silver - Wiley Interdisciplinary Reviews: RNA, 2015 - Wiley Online Library
The cerebral cortex, the brain structure responsible for our higher cognitive functions, is built
during embryonic development in a process called corticogenesis. During corticogenesis …

miR‐335 inhibited cell proliferation of lung cancer cells by target Tra2β

J Liu, T Bian, J Feng, L Qian, J Zhang, D Jiang… - Cancer …, 2018 - Wiley Online Library
Accumulating evidence has suggested that the dysregulation of mi RNA is an important
factor in the pathogenesis of lung cancer. Here, we demonstrate that miR‐335 expression is …

G3BP1-dependent mechanism suppressing protein aggregation in Huntington's models and its demise upon stress granule assembly

R Gutiérrez-Garcia, S Koyuncu… - Human molecular …, 2023 - academic.oup.com
Stress granules are membrane-less ribonucleoprotein organelles that assemble upon
exposure to stress conditions, but rapidly disassemble upon removal of stress. However …