Emerging blood–brain-barrier-crossing nanotechnology for brain cancer theranostics

W Tang, W Fan, J Lau, L Deng, Z Shen… - Chemical Society …, 2019 - pubs.rsc.org
Brain cancer, especially the most common type of glioblastoma, is highly invasive and
known as one of the most devastating and deadly neoplasms. Despite surgical and medical …

A holistic approach to targeting disease with polymeric nanoparticles

CJ Cheng, GT Tietjen, JK Saucier-Sawyer… - Nature reviews Drug …, 2015 - nature.com
The primary goal of nanomedicine is to improve clinical outcomes. To this end, targeted
nanoparticles are engineered to reduce non-productive distribution while improving …

In Situ Separable Nanovaccines with Stealthy Bioadhesive Capability for Durable Cancer Immunotherapy

L Yu, M Yu, W Chen, S Sun, W Huang… - Journal of the …, 2023 - ACS Publications
Because of tumor heterogeneity and the immunosuppressive tumor microenvironment, most
cancer vaccines typically do not elicit robust antitumor immunological responses in clinical …

Polymeric vehicles for nucleic acid delivery

AS Piotrowski-Daspit, AC Kauffman… - Advanced drug delivery …, 2020 - Elsevier
Polymeric vehicles are versatile tools for therapeutic gene delivery. Many polymers—when
assembled with nucleic acids into vehicles—can protect the cargo from degradation and …

Synthesis and characterization of curcumin loaded PLA—Hyperbranched polyglycerol electrospun blend for wound dressing applications

G Perumal, S Pappuru, D Chakraborty… - Materials Science and …, 2017 - Elsevier
This study is aimed to develop curcumin (Cur) incorporated electrospun nanofibers of a
blend of poly (lactic acid)(PLA) and hyperbranched polyglycerol (HPG) for wound healing …

Chemical approaches to synthetic drug delivery systems for systemic applications

D Braatz, M Cherri, M Tully, M Dimde… - Angewandte Chemie …, 2022 - Wiley Online Library
Poor water solubility and low bioavailability of active pharmaceutical ingredients (APIs) are
major causes of friction in the pharmaceutical industry and represent a formidable hurdle for …

Untangling mucosal drug delivery: engineering, designing, and testing nanoparticles to overcome the mucus barrier

J Watchorn, AJ Clasky, G Prakash… - ACS Biomaterials …, 2022 - ACS Publications
Mucus is a complex viscoelastic gel and acts as a barrier covering much of the soft tissue in
the human body. High vascularization and accessibility have motivated drug delivery to …

Nanotherapy for cancer: targeting and multifunctionality in the future of cancer therapies

A Ediriwickrema, WM Saltzman - ACS biomaterials science & …, 2015 - ACS Publications
Cancer continues to be a prevalent and lethal disease, despite advances in tumor biology
research and chemotherapy development. Major obstacles in cancer treatment arise from …

A sunblock based on bioadhesive nanoparticles

Y Deng, A Ediriwickrema, F Yang, J Lewis, M Girardi… - Nature materials, 2015 - nature.com
The majority of commercial sunblock preparations use organic or inorganic ultraviolet (UV)
filters. Despite protecting against cutaneous phototoxicity, direct cellular exposure to UV …

Nucleic acid drug vectors for diagnosis and treatment of brain diseases

ZG Lu, J Shen, J Yang, JW Wang, RC Zhao… - … and Targeted Therapy, 2023 - nature.com
Nucleic acid drugs have the advantages of rich target selection, simple in design, good and
enduring effect. They have been demonstrated to have irreplaceable superiority in brain …