Zebrafish is an essential model organism for studying cardiovascular diseases, given its
advantages of fast proliferation and high gene homology with humans. Zebrafish …

In the modern world, myocardial infarction is one of the most common cardiovascular
diseases, which are responsible for around 18 million deaths every year or almost 32% of all …

Anthracyclines are highly effective chemotherapeutics for antineoplastic treatment. However,
cumulative cardiotoxicity is the main side effect with poor prognosis. No mechanism-based …

Modifier genes contribute significantly to our understanding of pathophysiology in human
diseases; however, effective approaches to identify modifier genes are still lacking. Here, we …

Cardiomyopathies are a highly heterogeneous group of heart muscle disorders. More than
100 causative genes have been linked to various cardiomyopathies, which explain about …

Five years after the launch of the Disease Models & Mechanisms (DMM) Special Issue on
zebrafish as a disease model, the field has progressed significantly. Zebrafish have been …

Adult zebrafish is an emerging vertebrate model for studying genetic basis of
cardiomyopathies; but whether the simple fish heart can model essential features of …

Dilated cardiomyopathy (DCM) is a common heart muscle disorder characterized by
ventricular dilation and contractile dysfunction that is associated with significant morbidity …

To uncover the genetic basis of anthracycline-induced cardiotoxicity (AIC), we recently
established a genetic suppressor screening strategy in zebrafish. Here, we report the …

Age-associated changes in cardiac structure and function have been observed from the
molecular to whole organ level in humans and mammalian models. Understanding the …