The acute loss of kidney function has been diagnosed for many decades using the serum
concentration of creatinine—a muscle metabolite that is an insensitive and non-specific …

Perioperative hypotension is common and associated with poor outcomes, including acute
kidney injury (AKI). The mechanistic link between perioperative hypotension and AKI is at …

Background Acute kidney injury (AKI) is a common complication of cardiac surgery. An
intraoperative monitor of kidney perfusion is needed to identify patients at risk for AKI. The …

Chronic kidney disease (CKD) is a major public health problem. Accumulating evidence
suggests that CKD aggravates renal hypoxia, and in turn, renal hypoxia accelerates CKD …

Objectives: Angiotensin II is an emerging therapy for septic acute kidney injury, but it is
unknown if its vasoconstrictor action induces renal hypoxia. We therefore examined the …

Background Acute kidney injury (AKI) is common after cardiac surgery and profoundly
affects postoperative mortality and morbidity. There are no validated methods to assess risk …

Acute kidney injury (AKI) is a common complication following cardiac surgery performed on
cardiopulmonary bypass (CPB) and has important implications for prognosis. The aetiology …

Acute kidney injury (AKI) is common in the critically ill. Inadequate renal medullary tissue
oxygenation has been linked to its pathogenesis. Moreover, renal medullary tissue hypoxia …

Aim Urinary oxygen tension (uPO2) may provide an estimate of renal medullary PO2
(mPO2) and thus risk of acute kidney injury (AKI). We assessed the potential for variations in …

Objectives: To examine the effects of fluid bolus therapy on systemic hemodynamics, renal
blood flow, intrarenal perfusion and oxygenation, P o 2, renal function, and fluid balance in …