Chemistry of MRI contrast agents: current challenges and new frontiers
Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …
performed annually around the world. The contrast agents, which improve diagnostic …
Applications for transition-metal chemistry in contrast-enhanced magnetic resonance imaging
Contrast-enhanced magnetic resonance imaging (MRI) is an indispensable tool for
diagnostic medicine. However, safety concerns related to gadolinium in commercial MRI …
diagnostic medicine. However, safety concerns related to gadolinium in commercial MRI …
A manganese alternative to gadolinium for MRI contrast
Contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) are
routinely used to diagnose soft tissue and vascular abnormalities. However, safety concerns …
routinely used to diagnose soft tissue and vascular abnormalities. However, safety concerns …
Manganese‐Based Layered Double Hydroxide Nanoparticles as a T1‐MRI Contrast Agent with Ultrasensitive pH Response and High Relaxivity
Recently, Mn (II)‐containing nanoparticles have been explored widely as an attractive
alternative to Gd (III)‐based T1‐weighted magnetic resonance imaging (MRI) contrast …
alternative to Gd (III)‐based T1‐weighted magnetic resonance imaging (MRI) contrast …
A genetically encoded fluorescent sensor for manganese (II), engineered from lanmodulin
J Park, MB Cleary, D Li, JA Mattocks… - Proceedings of the …, 2022 - National Acad Sciences
The design of selective metal-binding sites is a challenge in both small-molecule and
macromolecular chemistry. Selective recognition of manganese (II)—the first-row transition …
macromolecular chemistry. Selective recognition of manganese (II)—the first-row transition …
Mn2+ Bispidine Complex Combining Exceptional Stability, Inertness, and MRI Efficiency
D Ndiaye, P Cieslik, H Wadepohl, A Pallier… - Journal of the …, 2022 - ACS Publications
As an essential metal ion and an efficient relaxation agent, Mn2+ holds a great promise to
replace Gd3+ in magnetic resonance imaging (MRI) contrast agent applications, if its stable …
replace Gd3+ in magnetic resonance imaging (MRI) contrast agent applications, if its stable …
Stable and inert Mn (II)-based and pH-responsive contrast agents
R Botár, E Molnár, G Trencsényi, J Kiss… - Journal of the …, 2020 - ACS Publications
Smart/intelligent contrast agent candidates for MRI based on Mn (II) ion are rare, as it usually
forms labile complexes with polyaminocarboxylate-type ligands. Here, we report the first …
forms labile complexes with polyaminocarboxylate-type ligands. Here, we report the first …
Mn (II) compounds as an alternative to Gd-based MRI probes
Mn (II) has several favorable physicochemical characteristics and a good toxicity profile,
which makes it a viable alternative to the Gd (III)-based MRI contrast agents currently used in …
which makes it a viable alternative to the Gd (III)-based MRI contrast agents currently used in …
A Class of FeIII Macrocyclic Complexes with Alcohol Donor Groups as Effective T1 MRI Contrast Agents
EM Snyder, D Asik, SM Abozeid, A Burgio… - Angewandte …, 2020 - Wiley Online Library
Early studies suggested that FeIII complexes cannot compete with GdIII complexes as T1
MRI contrast agents. Now it is shown that one member of a class of high‐spin macrocyclic …
MRI contrast agents. Now it is shown that one member of a class of high‐spin macrocyclic …
Relaxivity Enhancement of Hybrid Micelles via Modulation of Water Coordination Numbers for Magnetic Resonance Lymphography
Considerable efforts have been made to develop nanoparticle-based magnetic resonance
contrast agents (CAs) with high relaxivity. The prolonged rotational correlation time (τR) …
contrast agents (CAs) with high relaxivity. The prolonged rotational correlation time (τR) …