Oxidative stress and regulated cell death in Parkinson's disease

PA Dionísio, JD Amaral, CMP Rodrigues - Ageing research reviews, 2021 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide. Motor deficits usually associated with PD correlate with dopaminergic axonal …

Neuron-astrocyte interactions in Parkinson's disease

I Miyazaki, M Asanuma - Cells, 2020 - mdpi.com
Parkinson's disease (PD) is the second most common neurodegenerative disease. PD
patients exhibit motor symptoms such as akinesia/bradykinesia, tremor, rigidity, and postural …

Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism

P Lindholm, M Saarma - Molecular psychiatry, 2022 - nature.com
Midbrain dopamine neurons deteriorate in Parkinson's disease (PD) that is a progressive
neurodegenerative movement disorder. No cure is available that would stop the …

Promising drug targets and associated therapeutic interventions in Parkinson's disease

SN Rai, P Singh, R Varshney… - Neural regeneration …, 2021 - journals.lww.com
Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the
availability of symptomatic treatments, response towards the health of PD patients remains …

GDNF and Parkinson's disease: where next? A summary from a recent workshop

RA Barker, A Björklund, DM Gash… - Journal of …, 2020 - content.iospress.com
The concept of repairing the brain with growth factors has been pursued for many years in a
variety of neurodegenerative diseases including primarily Parkinson's disease (PD) using …

Neurotrophic factors in Parkinson's disease: clinical trials, open challenges and nanoparticle-mediated delivery to the brain

O Bondarenko, M Saarma - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
Neurotrophic factors (NTFs) are small secreted proteins that support the development,
maturation and survival of neurons. NTFs injected into the brain rescue and regenerate …

Intraputamenal cerebral dopamine neurotrophic factor in Parkinson's disease: a randomized, double‐blind, multicenter phase 1 trial

HJ Huttunen, S Booms, M Sjögren… - Movement …, 2023 - Wiley Online Library
Background Cerebral dopamine neurotrophic factor (CDNF) is an unconventional
neurotrophic factor that protects dopamine neurons and improves motor function in animal …

Neurotrophic factors for disease-modifying treatments of Parkinson's disease: gaps between basic science and clinical studies

P Chmielarz, M Saarma - Pharmacological Reports, 2020 - Springer
Background Neurotrophic factors are endogenous proteins promoting the survival of
different neural cells. Therefore, they elicited great interest as a possible treatment for …

HER-096 is a CDNF-derived brain-penetrating peptidomimetic that protects dopaminergic neurons in a mouse synucleinopathy model of Parkinson's disease

N Kulesskaya, A Bhattacharjee, KM Holmström… - Cell Chemical …, 2024 - cell.com
Cerebral dopamine neurotrophic factor (CDNF) is an unconventional neurotropic factor that
modulates unfolded protein response (UPR) pathway signaling and alleviates endoplasmic …

Molecularly imprinted polymer-based SAW sensor for label-free detection of cerebral dopamine neurotrophic factor protein

A Kidakova, R Boroznjak, J Reut, A Öpik… - Sensors and Actuators B …, 2020 - Elsevier
In this study we report on a surface acoustic wave (SAW) sensor modified with a molecularly
imprinted polymer (MIP) film that selectively recognizes the cerebral dopamine neurotrophic …