MicroRNA: function, detection, and bioanalysis

H Dong, J Lei, L Ding, Y Wen, H Ju, X Zhang - Chemical reviews, 2013 - ACS Publications
Mature microRNAs (miRNAs) are a class of evolutionally conserved, single-stranded, small
(approximately 19− 23 nucleotides), endogenously expressed, and non-protein-coding …

MicroRNA profiling: approaches and considerations

CC Pritchard, HH Cheng, M Tewari - Nature Reviews Genetics, 2012 - nature.com
MicroRNAs (miRNAs) are small RNAs that post-transcriptionally regulate the expression of
thousands of genes in a broad range of organisms in both normal physiological contexts …

MicroRNAs in human cancer

TA Farazi, JI Hoell, P Morozov, T Tuschl - MicroRNA cancer regulation …, 2013 - Springer
Mature microRNAs (miRNAs) are single-stranded RNA molecules of 20–23-nucleotide (nt)
length that control gene expression in many cellular processes. These molecules typically …

Genetic variation in microRNA networks: the implications for cancer research

BM Ryan, AI Robles, CC Harris - Nature reviews cancer, 2010 - nature.com
Many studies have highlighted the role that microRNAs have in physiological processes and
how their deregulation can lead to cancer. More recently, it has been proposed that the …

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis

S Cheloufi, CO Dos Santos, MMW Chong, GJ Hannon - Nature, 2010 - nature.com
The nucleolytic activity of animal Argonaute proteins is deeply conserved, despite its having
no obvious role in microRNA-directed gene regulation. In mice, Ago2 (also known as Eif2c2) …

miRNAs in human cancer

TA Farazi, JI Spitzer, P Morozov… - The Journal of …, 2011 - Wiley Online Library
Mature microRNAs (miRNAs) are single‐stranded RNA molecules of 20–23 nucleotide (nt)
length that control gene expression in many cellular processes. These molecules typically …

[HTML][HTML] A mammalian microRNA expression atlas based on small RNA library sequencing

P Landgraf, M Rusu, R Sheridan, A Sewer, N Iovino… - Cell, 2007 - cell.com
MicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or
translation of fully or partially sequence-complementary target mRNAs. In order to identify …

Discovering microRNAs from deep sequencing data using miRDeep

MR Friedländer, W Chen, C Adamidi, J Maaskola… - Nature …, 2008 - nature.com
The capacity of highly parallel sequencing technologies to detect small RNAs at
unprecedented depth suggests their value in systematically identifying microRNAs …

Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells

RD Morin, MD O'Connor, M Griffith… - Genome …, 2008 - genome.cshlp.org
MicroRNAs (miRNAs) are emerging as important, albeit poorly characterized, regulators of
biological processes. Key to further elucidation of their roles is the generation of more …

[HTML][HTML] MicroRNA function in animal development

E Wienholds, RHA Plasterk - FEBS letters, 2005 - Elsevier
MicroRNAs (miRNAs) are small non-coding RNA molecules that post-transcriptionally
regulate gene expression by base-pairing to mRNAs. Hundreds of miRNAs have been …