The evolving role of tissue-resident memory T cells in infections and cancer

S Yenyuwadee, JL Sanchez-Trincado Lopez… - Science …, 2022 - science.org
Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in
tissues. TRM form an integral part of the immune sensing network and have the ability to …

The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues

L Kok, D Masopust, TN Schumacher - Nature Reviews Immunology, 2022 - nature.com
CD8+ tissue resident memory T cells (TRM cells) are essential for immune defence against
pathogens and malignancies, and the molecular processes that lead to TRM cell formation …

[HTML][HTML] Tissue resident memory T cells in the respiratory tract

MZM Zheng, LM Wakim - Mucosal immunology, 2022 - Elsevier
Owing to their capacity to rapidly spread across the population, airborne pathogens
represent a significant risk to global health. Indeed, several of the past major global …

Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses

FM Behr, L Parga-Vidal, NAM Kragten… - Nature …, 2020 - nature.com
Tissue-resident memory CD8+ T cells (TRM cells) are crucial in protecting against
reinvading pathogens, but the impact of reinfection on their tissue confinement and …

Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma

N Zakeri, A Hall, L Swadling, LJ Pallett… - Nature …, 2022 - nature.com
Immunotherapy is now the standard of care for advanced hepatocellular carcinoma (HCC),
yet many patients fail to respond. A major unmet goal is the boosting of T-cells with both …

Diversity of group 1 innate lymphoid cells in human tissues

N Jaeger, AU Antonova, D Kreisel, F Roan… - Nature …, 2024 - nature.com
Group 1 innate lymphoid cells (ILC1s) are cytotoxic and interferon gamma-producing
lymphocytes lacking antigen-specific receptors, which include ILC1s and natural killer (NK) …

T cell receptor signaling strength establishes the chemotactic properties of effector CD8+ T cells that control tissue-residency

M Abdelbary, SJ Hobbs, JS Gibbs, JW Yewdell… - Nature …, 2023 - nature.com
Tissue-resident memory (TRM) CD8+ T cells are largely derived from recently activated
effector T cells, but the mechanisms that control the extent of TRM differentiation within …

Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues

C Friedrich, RLRE Taggenbrock… - Nature …, 2021 - nature.com
Innate lymphoid cells (ILCs) participate in tissue homeostasis, inflammation, and early
immunity against infection. It is unclear how ILCs acquire effector function and whether these …

[HTML][HTML] Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes

YH Lin, HG Duong, AE Limary, ES Kim, P Hsu… - Immunity, 2023 - cell.com
Tissue-resident memory CD8+ T (T RM) cells are a subset of memory T cells that play a
critical role in limiting early pathogen spread and controlling infection. T RM cells exhibit …

Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes

L Parga-Vidal, FM Behr, NAM Kragten, B Nota… - Science …, 2021 - science.org
Tissue-resident memory CD8+ T cells (TRM) constitute a noncirculating memory T cell
subset that provides early protection against reinfection. However, how TRM arise from …