Hemostasis encompasses the tightly regulated processes of blood clotting, platelet
activation, and vascular repair. After wounding, the hemostatic system engages a plethora of …

Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …

Inflammatory diseases have become increasingly prevalent with industrialization. To
address this, numerous anti-inflammatory agents and molecular targets have been …

The homeostatic blood protease, activated protein C (APC), can function as (1) an
antithrombotic on the basis of inactivation of clotting factors Va and VIIIa;(2) a cytoprotective …

Discovered in the 1990s, protease activated receptors 1 (PARs) are membrane-spanning
cell surface proteins that belong to the G protein coupled receptor (GPCR) family. A defining …

The family of G protein‐coupled receptors (GPCRs) constitutes the largest class of signalling
receptors in the human genome, controlling vast physiological responses and are the target …

Endothelial cell protein C receptor (EPCR) was first identified and isolated as a cellular
receptor for protein C on endothelial cells. EPCR plays a crucial role in the protein C …

The protein C pathway provides multiple important functions to maintain a regulated balance
between hemostasis and host defense systems in response to vascular and inflammatory …

Protein C is a plasma serine protease zymogen whose active form, activated protein C
(APC), exerts potent anticoagulant activity. In addition to its antithrombotic role as a plasma …

Although it has been known since the 1960s that trypsin and chymotrypsin can mimic
hormone action in tissues, it took until the 1990s to discover that serine proteinases can …