Advances in the immunology and genetics of leprosy

Z Mi, H Liu, F Zhang - Frontiers in immunology, 2020 - frontiersin.org
Leprosy, a disease caused by the intracellular parasite Mycobacterium leprae or
Mycobacterium lepromatosis, has affected humans for more than 4,000 years and is a …

Targeting autophagy as a strategy for developing new vaccines and host-directed therapeutics against mycobacteria

EJ Strong, S Lee - Frontiers in microbiology, 2021 - frontiersin.org
Mycobacterial disease is an immense burden worldwide. This disease group includes
tuberculosis, leprosy (Hansen's disease), Buruli Ulcer, and non-tuberculous mycobacterial …

2, 4‐dichlorophenoxyacetic acid induces ROS activation in NLRP3 inflammatory body‐induced autophagy disorder in microglia and the protective effect of Lycium …

J Zhou, F Wang, L Jia, R Chai, H Wang… - Environmental …, 2022 - Wiley Online Library
Abstract The pesticide 2, 4‐dichlorophenoxyacetic acid (2, 4‐D) exerts neurotoxic effects;
however, its action mechanism remains unclear. Here, we used BV2 cells as a model and …

Reduction of host cell mitochondrial activity as Mycobacterium leprae's strategy to evade host innate immunity

MF Oliveira, RCA Medeiros, BS Mietto… - Immunological …, 2021 - Wiley Online Library
Leprosy is a much‐feared incapacitating infectious disease caused by Mycobacterium
leprae or M lepromatosis, annually affecting roughly 200,000 people worldwide. During host …

Phenolic glycolipid‐1 of Mycobacterium leprae is involved in human Schwann cell line ST8814 neurotoxic phenotype

KCV Girardi, BS Mietto, K dos Anjos Lima… - Journal of …, 2023 - Wiley Online Library
Leprosy is a chronic infectious disease caused by Mycobacterium leprae infection in
Schwann cells. Axonopathy is considered a hallmark of leprosy neuropathy and is …

Immune dysregulation and inflammation causing hypopigmentation in post kala-azar dermal leishmaniasis: partners in crime?

R Sengupta, M Roy, NS Dey, PM Kaye… - Trends in …, 2023 - cell.com
Post kala-azar dermal leishmaniasis (PKDL), a heterogeneous dermal sequela of visceral
leishmaniasis (VL), is challenging in terms of its etiopathogenesis. Hypopigmentation is a …

MicroRNA biomarkers in leprosy: insights from the Northern Brazilian Amazon population and their implications in disease immune-physiopathology

MÁ Cáceres-Durán, P Pinto, L Magalhães… - Frontiers in …, 2024 - frontiersin.org
Leprosy, or Hansen's Disease, is a chronic infectious disease caused by Mycobacterium
leprae that affects millions of people worldwide. Despite persistent efforts to combat it …

AIM2 nuclear exit and inflammasome activation in chronic obstructive pulmonary disease and response to cigarette smoke

HB Tran, R Hamon, H Jersmann, MP Ween… - Journal of …, 2021 - Springer
Introduction The role inflammasomes play in chronic obstructive pulmonary disease (COPD)
is unclear. We hypothesised that the AIM2 inflammasome is activated in the airways of …

Xenophagy as a Strategy for Mycobacterium leprae Elimination during Type 1 or Type 2 Leprosy Reactions: A Systematic Review

DDN Cerqueira, ALS Pereira, AEC da Costa… - Pathogens, 2023 - mdpi.com
Background: Mycobacterium leprae is an intracellular bacillus that causes leprosy, a
neglected disease that affects macrophages and Schwann cells. Leprosy reactions are …

Unlocking the impact of translocated promoter region (TPR) on autophagy and cancer progression

FRP Dewi, H Hartono - Egyptian Journal of Basic and Applied …, 2024 - Taylor & Francis
Translocated promoter region (TPR) serves as a crucial component within the nuclear pore
complex (NPC), situated in the nuclear basket region. Initially identified through the TPR-Met …