The schizophrenia syndrome, circa 2024: What we know and how that informs its nature

R Tandon, H Nasrallah, S Akbarian… - Schizophrenia …, 2024 - Elsevier
With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …

[HTML][HTML] Inhibition of glycogen synthase kinase 3 by lithium, a mechanism in search of specificity

D Chatterjee, JM Beaulieu - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
Inhibition of Glycogen synthase kinase 3 (GSK3) is a popular explanation for the effects of
lithium ions on mood regulation in bipolar disorder and other mental illnesses, including …

[HTML][HTML] Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca2+ entry and accelerated differentiation

T Hewitt, B Alural, M Tilak, J Wang, N Becke… - Molecular …, 2023 - nature.com
While most of the efforts to uncover mechanisms contributing to bipolar disorder (BD)
focused on phenotypes at the mature neuron stage, little research has considered events …

[HTML][HTML] Deep exome sequencing identifies enrichment of deleterious mosaic variants in neurodevelopmental disorder genes and mitochondrial tRNA regions in …

M Nishioka, J Takayama, N Sakai, A Kazuno… - Molecular …, 2023 - nature.com
Bipolar disorder (BD) is a global medical issue, afflicting around 1% of the population with
manic and depressive episodes. Despite various genetic studies, the genetic architecture …

A review on the role of genetic mutations in the autism spectrum disorder

S Ghafouri-Fard, A Pourtavakoli, BM Hussen… - Molecular …, 2023 - Springer
Autism spectrum disorder (ASD) is among the most widespread neurodevelopmental
diseases, with an approximate prevalence rate of 1 in 59. From a genetic point of view, this …

[HTML][HTML] A systematic review of the human accelerated regions in Schizophrenia and related disorders: where the evolutionary and neurodevelopmental hypotheses …

M Guardiola-Ripoll, M Fatjó-Vilas - International Journal of Molecular …, 2023 - mdpi.com
Schizophrenia is a psychiatric disorder that results from genetic and environmental factors
interacting and disrupting neurodevelopmental trajectories. Human Accelerated Regions …

A brainwide risk score for psychiatric disorder evaluated in a large adolescent population reveals increased divergence among higher-risk groups relative to control …

W Yan, GD Pearlson, Z Fu, X Li, A Iraji, J Chen, J Sui… - Biological …, 2024 - Elsevier
Background Accurate psychiatric risk assessment requires biomarkers that are both stable
and adaptable to development. Functional network connectivity (FNC), which steadily …

Astrotactin 2 (ASTN2) regulates emotional and cognitive functions by affecting neuronal morphogenesis and monoaminergic systems

T Ito, M Yoshida, T Aida, I Kushima… - Journal of …, 2023 - Wiley Online Library
Abstract Astrotactin2 (ASTN2) regulates neuronal migration and synaptic strength through
the trafficking and degradation of surface proteins. Deletion of ASTN2 in copy number …

[HTML][HTML] Genomic and Reverse Translational Analysis Discloses a Role for Small GTPase RhoA Signaling in the Pathogenesis of Schizophrenia: Rho-Kinase as a …

R Tanaka, K Yamada - International Journal of Molecular Sciences, 2023 - mdpi.com
Schizophrenia is one of the most serious psychiatric disorders and is characterized by
reductions in both brain volume and spine density in the frontal cortex. RhoA belongs to the …

[HTML][HTML] Analysis of human neuronal cells carrying ASTN2 deletion associated with psychiatric disorders

Y Hayashi, H Okumura, Y Arioka, I Kushima… - Translational …, 2024 - nature.com
Recent genetic studies have found common genomic risk variants among psychiatric
disorders, strongly suggesting the overlaps in their molecular and cellular mechanism. Our …