NAFLD: mechanisms, treatments, and biomarkers

F Nassir - Biomolecules, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver
disease (MAFLD), is one of the most common causes of liver diseases worldwide. NAFLD is …

Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

P Rada, Á González-Rodríguez, C García-Monzón… - Cell death & …, 2020 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic …

High-glucose or-fructose diet cause changes of the gut microbiota and metabolic disorders in mice without body weight change

MH Do, E Lee, MJ Oh, Y Kim, HY Park - Nutrients, 2018 - mdpi.com
High fat diet-induced changes in gut microbiota have been linked to intestinal permeability
and metabolic endotoxemia, which is related to metabolic disorders. However, the influence …

Advances in understanding of the role of lipid metabolism in aging

KW Chung - Cells, 2021 - mdpi.com
During aging, body adiposity increases with changes in the metabolism of lipids and their
metabolite levels. Considering lipid metabolism, excess adiposity with increased lipotoxicity …

[HTML][HTML] High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice

RA van der Heijden, F Sheedfar, MC Morrison… - Aging (Albany …, 2015 - ncbi.nlm.nih.gov
Metabolic inflammation in adipose tissue and the liver is frequently observed as a result of
diet-induced obesity in human and rodent studies. Although the adipose tissue and the liver …

PCSK9 induces CD36 degradation and affects long-chain fatty acid uptake and triglyceride metabolism in adipocytes and in mouse liver

A Demers, S Samami, B Lauzier… - … , and vascular biology, 2015 - Am Heart Assoc
Objective—Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes the degradation
of the low-density lipoprotein receptor thereby elevating plasma low-density lipoprotein …

C57BL/6J substrain differences in response to high-fat diet intervention

MS Siersbæk, N Ditzel, EK Hejbøl, SM Præstholm… - Scientific reports, 2020 - nature.com
Abstract C57BL/6J-related mouse strains are widely used animal models for diet-induced
obesity (DIO). Multiple vendors breed C57BL/6J-related substrains which may introduce …

Targeting CD36 as biomarker for metastasis prognostic: how far from translation into clinical practice?

AM Enciu, E Radu, ID Popescu… - BioMed research …, 2018 - Wiley Online Library
Metastasis requires cellular changes related to cell‐to‐cell and cell‐to‐matrix adhesion,
immune surveillance, activation of growth and survival signalling pathways, and epigenetic …

The role of PCSK9 in NAFLD/NASH and therapeutic implications of PCSK9 inhibition

AA Momtazi-Borojeni, M Banach… - Expert Review of …, 2022 - Taylor & Francis
Introduction There are inconsistent findings regarding the effect of lipid-lowering agents on
nonalcoholic fatty liver disease (NAFLD). Proprotein Convertase Subtilisin/Kexin type 9 …

CD36 signal transduction in metabolic diseases: novel insights and therapeutic targeting

U Karunakaran, S Elumalai, JS Moon, KC Won - Cells, 2021 - mdpi.com
The cluster of differentiation 36 (CD36) is a scavenger receptor present on various types of
cells and has multiple biological functions that may be important in inflammation and in the …