Neutrophils are produced in the bone marrow from stem cells that proliferate and
differentiate to mature neutrophils fully equipped with an armory of granules. These contain …

When cancer metastasizes to bone, considerable pain and deregulated bone remodelling
occurs, greatly diminishing the possibility of cure. Metastasizing tumour cells mobilize and …

Immune protection relies on the capacity of neutrophils to infiltrate challenged tissues. Naive
tissues, in contrast, are believed to remain free of these cells and protected from their toxic …

Neutrophils are a major component of the innate immune response. Their homeostasis is
maintained, in part, by the regulated release of neutrophils from the bone marrow …

The CXC chemokine receptor 4 (CXCR4) in endothelial cells (ECs) and vascular smooth
muscle cells (VSMCs) is crucial for vascular integrity. The atheroprotective functions of …

Cells of the innate and adaptive immune systems are the progeny of a variety of
haematopoietic precursors, the most primitive of which is the haematopoietic stem cell …

Chemokines and chemokine receptors regulate multiple processes such morphogenesis,
angiogenesis and immune responses. Among the chemokine receptors, CXCR4 stands out …

Bone marrow is thought to be a primary hematopoietic organ. However, accumulated
evidences demonstrate that active function and trafficking of immune cells, including …

The bone marrow microenvironment contains a heterogeneous population of stromal cells
organized into niches that support hematopoietic stem cells (HSCs) and other lineage …

Cancer stem cells have been proposed to be important for initiation, maintenance and
recurrence of various malignancies, including acute myeloid leukemia (AML),,. We have …