Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …

Current management of major depression, a common and debilitating disorder with a high
social and personal cost, is far from satisfactory. All available antidepressants act through …

Contemporary biological psychiatry uses experimental animal models to increase our
understanding of affective disorder pathogenesis. Modern anxiolytic drug discovery mainly …

Melatonin is known to possess several properties of value for healthy aging, as a direct and
indirect antioxidant, protectant and modulator of mitochondrial function, antiexcitotoxic …

Background: Melatonin (MLT) is a pleiotropic neurohormone controlling many physiological
processes and whose dysfunction may contribute to several different diseases, such as …

Agomelatine behaves both as a potent agonist at melatonin MT1 and MT2 receptors and as
a neutral antagonist at 5‐HT2C receptors. Accumulating evidence in a broad range of …

Background: Recently, neuroinflammation and the immune-kynurenine pathway have
received increased attention in the psychoimmunology field of major depressive disorder …

Background: Agomelatine is a novel agent that acts on melatonergic (MT 1, MT 2) receptors
and serotonergic (5-HT 2C) receptors. Preclinical data and data from clinical trials in major …

Generalized anxiety disorder (GAD), the most frequently diagnosed form of anxiety, is
usually treated by cognitive-behavioural approaches or medication; in particular …

Exogenous melatonin is used in a number of situations, first and foremost in the treatment of
sleep disorders and jet leg. However, the hypnotic, antinociceptive, and anticonvulsant …