TDP-43 is an RNA-binding protein with a crucial nuclear role in splicing, and mislocalises
from the nucleus to the cytoplasm in a range of neurodegenerative disorders. TDP-43 …

The genetic and molecular basis of ALS is increasingly examined on single-cell resolution.
In the past 2 years, the understanding of the downstream mechanisms of several ALS genes …

Loss of nuclear TDP-43 is a hallmark of neurodegeneration in TDP-43 proteinopathies,
including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TDP-43 …

Although loss of TAR DNA-binding protein 43 kDa (TDP-43) splicing repression is well
documented in postmortem tissues of amyotrophic lateral sclerosis (ALS) and frontotemporal …

Abstract Background Inclusions of TAR DNA-binding protein 43 kDa (TDP-43) has been
designated limbic-predominant, age-related TDP-43 encephalopathy (LATE), with or without …

Nuclear clearance and cytoplasmic accumulations of the RNA-binding protein TDP-43 are
pathological hallmarks in almost all patients with amyotrophic lateral sclerosis (ALS) and up …

The mRNA transcript of the human STMN2 gene, encoding for stathmin-2 protein (also
called SCG10), is profoundly impacted by TAR DNA-binding protein 43 (TDP-43) loss of …

Amyotrophic lateral sclerosis (ALS) is a disease characterized by upper and lower motor
neuron (MN) loss with a signature feature of cytoplasmic aggregates containing TDP-43 …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by many
diverse genetic etiologies. Although therapeutics that specifically target causal mutations …

Motoneurons critically depend on precise spatial and temporal control of translation for axon
growth and the establishment and maintenance of neuromuscular connections. While …