GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of
exciting new discoveries provides compelling evidence that disruptions in a number of key …

The teleology of sex differences has been argued since at least as early as Aristotle's
controversial Generation of Animals more than 300 years BC, which reflects the sex bias of …

Total body potassium content and proper distribution of potassium across the cell membrane
is of critical importance for normal cellular function. Potassium homeostasis is maintained by …

Sodium-glucose cotransporter 2 (SGLT2) inhibitors exert hypoglycemic and diuretic effects
by inhibiting the absorption of sodium and glucose from the proximal tubule. Currently …

From early unicellular organisms that formed in salty water environments to complex
organisms that live on land away from water, cells have had to protect a homeostatic internal …

A single protein-rich meal (or an infusion of amino acids) is known to increase the
glomerular filtration rate (GFR) for a few hours, a phenomenon known as “hyperfiltration.” It …

Membrane voltage controls the function of excitable cells and is mainly a consequence of
the ratio between the extra-and intracellular potassium concentration. Potassium …

Gain-of-function mutations in with no lysine (K) 1 (WNK1) and WNK4 genes are responsible
for familial hyperkalemic hypertension (FHHt), a rare, inherited disorder characterized by …

The intraneuronal ionic composition is an important determinant of brain functioning. There
is growing evidence that aberrant homeostasis of the intracellular concentration of Cl−([Cl−] …

Loop and thiazide diuretics have been cornerstones of clinical management of hypertension
and fluid overload conditions for more than five decades. The hunt for their molecular targets …