RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …

Schlafen (SLFN) genes belong to a vertebrate gene family encoding proteins with high
sequence homology. However, each SLFN is functionally divergent and differentially …

The Schlafen family belongs to the interferon-stimulated genes and its members are
involved in cell cycle regulation, T cell quiescence, inhibition of viral replication, DNA-repair …

Simple Summary Chemotherapeutic DNA-damaging agents targeting replication are widely
used but predictive rationales for drug combinations and patient selection still need clinical …

Abstract Schlafen11 (SLFN11) inactivation occurs in approximately 50% of cancer cell lines
and in a large fraction of patient tumor samples, which leads to chemoresistance. Therefore …

Faithful genome duplication is a challenging task for dividing mammalian cells, particularly
under replication stress where timely resolution of late replication intermediates (LRIs) …

The Schlafen (SLFN) 11 gene has been implicated in various biological processes such as
suppression of HIV replication, replication stress response, and sensitization of cancer cells …

PARP inhibitors (PARPis) were initially developed as DNA repair inhibitors that inhibit the
catalytic activity of PARP1 and PARP2 and are expected to induce synthetic lethality in …

We have recently discovered Japanese children with a novel Fanconi anemia–like inherited
bone marrow failure syndrome (IBMFS). This disorder is likely caused by the loss of a …

Hematopoietic stem cells (HSCs) are susceptible to replication stress, which is a major
contributor to HSC defects in Fanconi anemia (FA). Here, we report that HSCs relax the …