SUMMARY Herpes simplex virus 1 (HSV-1) is very successful in establishing acute and
latent infections in humans by counteracting host antiviral innate immune responses. HSV-1 …

Neuroinflammation is a critical degradative condition affecting neurons in the brain.
Progressive neurodegenerative conditions such as Alzheimer's disease and Parkinson's …

Pseudorabies virus (PRV) has evolved various immune evasion mechanisms that target
host antiviral immune responses. However, it is unclear whether and how PRV encoded …

Cyclic GMP-AMP synthase (cGAS) plays a key role in the innate immune responses to both
DNA and RNA virus infection. Here, we found that enterovirus 71 (EV-A71), Seneca Valley …

Interferons are a group of immunomodulatory substances produced by the human immune
system in response to the presence of pathogens, especially during viral and bacterial …

The neuroinflammatory responses following ischemic stroke cause irreversible nerve cell
death. Cell free-double strand DNA (dsDNA) segments from ischemic tissue debris are …

The interferon (IFN) system is one of the first lines of defense activated against invading viral
pathogens. Upon secretion, IFNs activate a signaling cascade resulting in the production of …

Cytomegalovirus (CMV) has successfully established a long-lasting latent infection in
humans due to its ability to counteract the host antiviral innate immune response. During …

Herpes simplex viruses (HSVs) are experts in establishing persistent infection in immune-
competent humans, in part by successfully evading immune activation through diverse …

Pseudorabies virus is a typical swine alphaherpesvirus, which can cause obvious
neurological disorders and reproductive failure in pigs. It is capable of evading host antiviral …