Aging is considered the deterioration of physiological functions along with an increased
mortality rate. This scientific review focuses on the central importance of genomic instability …

Aging is a nearly inescapable trait among organisms yet lifespan varies tremendously
across different species and spans several orders of magnitude in vertebrates alone. This …

Exercise promotes functional improvements in aged tissues, but the extent to which it
simulates partial molecular reprogramming is unknown. Using transcriptome profiling from …

Aging is a continuous degenerative process caused by a progressive decline of cell and
tissue functions in an organism. It is induced by the accumulation of damage that affects …

ABSTRACT 'Age reprogramming'refers to the process by which the molecular and cellular
pathways of a cell that are subject to age-related decline are rejuvenated without passage …

The inexorability of the aging process has sparked the curiosity of human beings since
ancient times. However, despite this interest and the extraordinary scientific advances in the …

Studies on human telomeres have established that telomeres exert a significant influence on
lifespan and health of organisms. However, recent research has indicated that the original …

Nicotinamide adenine dinucleotide (NAD+) has recently attracted much attention due to its
role in aging and lifespan extension. NAD+ directly and indirectly affects many cellular …

Sulfoxide synthase OvoA is the key enzyme involved in the biosynthesis of ovothiols (OSHs),
secondary metabolites endowed with unique antioxidant properties. Understanding the …

The demersal fish orange roughy (Hoplostethus atlanticus) can live for up to 250 years,
twenty times more than its congener silver roughy (Hoplostethus mediterraneus). Studies of …