Pyrethroids (PY) are synthetic pesticides used in many applications ranging from large-scale
agriculture to household maintenance. Their classical mechanisms of action are associated …

Background Arrhythmias are one manifestation of the cardiotoxicity that results from
doxorubicin (Doxo) administration. Although cardiotoxicity is an anticipated outcome in …

Hypothyroidism is the most frequent endocrine pathology. Although clinical or overt
hypothyroidism has been traditionally associated to low T3/T4 and high thyrotropin (TSH) …

Introduction Amiodarone (AMD) is a clinically used drug to treat arrhythmias with significant
effect upon the cardiac sodium channel Na v 1.5. AMD has a pKa of 6.56, and changes in …

Eugenol is an aromatic compound used in the manufacture of medicines, perfumes,
cosmetics and as an anaesthetic due to the ability of the drug to block the neuronal isoform …

Background Amiodarone (AMIO) is an antiarrhythmic drug with the pKa in the physiological
range. Here, we explored how mild extracellular pH (pHe) changes shape the interaction of …

O hipotireoidismo é uma condição endócrina comum, caracterizada pela produção
insuficiente de hormônios tireoidianos. Essa disfunção afeta aproximadamente 4, 6% da …