Role of non‐coding variants in cardiovascular disease

K Heshmatzad, N Naderi, M Maleki… - Journal of Cellular …, 2023 - Wiley Online Library
Cardiovascular diseases (CVDs) constitute one of the significant causes of death worldwide.
Different pathological states are linked to CVDs, which despite interventions and treatments …

[HTML][HTML] A translational neuroscience perspective on loneliness: Narrative review focusing on social interaction, illness and oxytocin

S Barton, A Zovko, C Müller, Q Krabichler… - Neuroscience & …, 2024 - Elsevier
This review addresses key findings on loneliness from the social, neurobiological and
clinical fields. From a translational perspective, results from studies in humans and animals …

Loneliness and depression: bidirectional mendelian randomization analyses using data from three large genome-wide association studies

DA Sbarra, FA Ramadan, KW Choi, JL Treur… - Molecular …, 2023 - nature.com
Major depression (MD) is a serious psychiatric illness afflicting nearly 5% of the world's
population. A large correlational literature suggests that loneliness is a prospective risk …

Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes

L Rødevand, S Bahrami, O Frei, Y Chu… - Translational …, 2021 - nature.com
Patients with bipolar disorder (BIP) have a high risk of cardiovascular disease (CVD),
despite considerable individual variation. The mechanisms underlying comorbid CVD in BIP …

Psychiatric disorders and subsequent risk of cardiovascular disease: a longitudinal matched cohort study across three countries

Q Shen, DH Mikkelsen, LB Luitva, H Song… - …, 2023 - thelancet.com
Background Several psychiatric disorders have been associated with increased risk of
cardiovascular disease (CVD), however, the role of familial factors and the main disease …

Shared genetic loci between schizophrenia and white blood cell counts suggest genetically determined systemic immune abnormalities

NE Steen, Z Rahman, A Szabo… - Schizophrenia …, 2023 - academic.oup.com
Background Immune mechanisms are indicated in schizophrenia (SCZ). Recent genome-
wide association studies (GWAS) have identified genetic variants associated with SCZ and …

[HTML][HTML] Breaking the vicious cycle: The interplay between loneliness, metabolic illness, and mental health

M Ahmed, I Cerda, M Maloof - Frontiers in Psychiatry, 2023 - frontiersin.org
Loneliness, or perceived social isolation, is a leading predictor of all-cause mortality and is
increasingly considered a public health epidemic afflicting significant portions of the general …

Genome-wide analysis of schizophrenia and multiple sclerosis identifies shared genomic loci with mixed direction of effects

M Ahangari, E Everest, TH Nguyen, BC Verrelli… - Brain, Behavior, and …, 2022 - Elsevier
Common genetic variants identified in genome-wide association studies (GWAS) show
varying degrees of genetic pleiotropy across complex human disorders. Clinical studies of …

[HTML][HTML] Prominent health problems, socioeconomic deprivation, and higher brain age in lonely and isolated individuals: A population-based study

AMG de Lange, T Kaufmann, DS Quintana… - Behavioural Brain …, 2021 - Elsevier
Loneliness is linked to increased risk for Alzheimer's disease, but little is known about
factors potentially contributing to adverse brain health in lonely individuals. In this study, we …

Loneliness, depression, and genetics in the elderly: Prognostic factors of a worse health condition?

ML Delgado-Losada, J Bouhaben… - International Journal of …, 2022 - mdpi.com
Loneliness is considered a prognostic factor for poorer health status in the elderly. It is
proposed to analyze the role of loneliness in health status in terms of various factors. A total …