Protein moonlighting by a target gene dominates phenotypic divergence of the Sef1 transcriptional regulatory network in yeasts

PC Hsu, TC Lu, PH Hung, JY Leu - Nucleic Acids Research, 2024 - academic.oup.com
Transcriptional rewiring generates phenotypic novelty, acting as an important mechanism
contributing to evolutionary development, speciation, and adaptation in all organisms. The …

Progressive transcriptomic shifts in evolved yeast strains following gene knockout

B Jiang, C Xiao, L Liu - Iscience, 2024 - cell.com
Gene knockout disrupts cellular homeostasis, altering gene expression, and phenotypes.
We investigated whether cells return to their pre-knockout transcriptomic state through …