Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

Inflammation triggered by SARS-CoV-2 and ACE2 augment drives multiple organ failure of severe COVID-19: molecular mechanisms and implications

M Iwasaki, J Saito, H Zhao, A Sakamoto, K Hirota, D Ma - Inflammation, 2021 - Springer
The widespread occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has led to a pandemic of coronavirus disease 2019 (COVID-19). The S spike protein …

The immunology of atherosclerosis

A Gisterå, GK Hansson - Nature reviews nephrology, 2017 - nature.com
Cardiovascular disease is the leading cause of death worldwide, both in the general
population and among patients with chronic kidney disease (CKD). In most cases, the …

2012 ACCF/AHA focused update incorporated into the ACCF/AHA 2007 guidelines for the management of patients with unstable angina/non–ST-elevation myocardial …

2007 Writing Committee Members, JL Anderson… - Circulation, 2013 - Am Heart Assoc
It is important that the medical profession play a significant role in critically evaluating the
use of diagnostic procedures and therapies as they are introduced and tested in the …

NFkappaB is a key player in the crosstalk between inflammation and cardiovascular diseases

A Fiordelisi, G Iaccarino, C Morisco, E Coscioni… - International journal of …, 2019 - mdpi.com
Inflammation is a key mechanism of cardiovascular diseases. It is an essential component of
atherosclerosis and a significant risk factor for the development of cardiovascular events. In …

Inflammation, atherosclerosis, and coronary artery disease

GK Hansson - New England journal of medicine, 2005 - Mass Medical Soc
Inflammation, Atherosclerosis, and Coronary Artery Disease | New England Journal of Medicine
Skip to main content The New England Journal of Medicine homepage Advanced Search …

[HTML][HTML] Muscle as an endocrine organ: focus on muscle-derived interleukin-6

BK Pedersen, MA Febbraio - Physiological reviews, 2008 - journals.physiology.org
Skeletal muscle has recently been identified as an endocrine organ. It has, therefore, been
suggested that cytokines and other peptides that are produced, expressed, and released by …

Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men

PM Ridker, M Cushman, MJ Stampfer… - New England journal …, 1997 - Mass Medical Soc
Background Inflammation may be important in the pathogenesis of atherothrombosis. We
studied whether inflammation increases the risk of a first thrombotic event and whether …

C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose …

JS Yudkin, CDA Stehouwer, JJ Emeis… - … , and vascular biology, 1999 - Am Heart Assoc
C-reactive protein, a hepatic acute phase protein largely regulated by circulating levels of
interleukin-6, predicts coronary heart disease incidence in healthy subjects. We have shown …

ACC/AHA 2007 guidelines for the management of patients with unstable angina/non–ST-elevation myocardial infarction: a report of the American College of …

JL Anderson, CD Adams, EM Antman… - Journal of the American …, 2007 - jacc.org
The ACC/AHA Task Force on Practice Guidelines was formed to make recommendations
regarding the diagnosis and treatment of patients with known or suspected cardiovascular …