The association of airborne particulate matter exposure with the deteriorating function of the
cardiovascular system is fundamentally driven by the impairment of mitochondrial-nuclear …

Metabolic syndrome (MetS) is a precursor to the major health diseases associated with high
mortality in industrialized countries: cardiovascular disease and diabetes. An important …

Background The relationship between mitochondrial DNA copy number (mtDNA CN) and
cardiovascular disease remains elusive. Methods and Results We performed cross …

Background This study used a bidirectional 2-sample Mendelian randomization study to
investigate the potential causal links between mtDNA copy number and cardiometabolic …

Background and Objectives Previous studies suggest that lower mitochondrial DNA
(mtDNA) copy number (CN) is associated with neurodegenerative diseases. However …

Vascular aging, a major risk factor for cardiovascular disease, contributes to morbidity and
mortality in older people. Mitochondria play an important role in vascular aging. In …

Objective This study aimed to investigate the associations between peripheral blood
leukocyte mitochondrial copy number, metabolic syndrome, and adiposity-related body …

Mitochondrial dysfunction is a common denominator in both biological aging and
cardiovascular disease (CVD) pathology. Understanding the protagonist role of …

Mitochondrial DNA copy number (mtDNAcn) dynamics throughout childhood are poorly
understood. We profiled mtDNAcn from birth through adolescence and evaluated how the …

Heredity of familial hypercholesterolemia (FH) can present as a dominant monogenic
disorder of polygenic origin or with no known genetic cause. In addition, the variability of the …