Maraviroc: a review of its use in HIV infection and beyond
SM Woollard, GD Kanmogne - Drug design, development and …, 2015 - Taylor & Francis
The human immunodeficiency virus-1 (HIV-1) enters target cells by binding its envelope
glycoprotein gp120 to the CD4 receptor and/or coreceptors such as CC chemokine receptor …
glycoprotein gp120 to the CD4 receptor and/or coreceptors such as CC chemokine receptor …
Current ARTs, virologic failure, and implications for AIDS management: a systematic review
FET Foka, HT Mufhandu - Viruses, 2023 - mdpi.com
Antiretroviral therapies (ARTs) have revolutionized the management of human
immunodeficiency virus (HIV) infection, significantly improved patient outcomes, and …
immunodeficiency virus (HIV) infection, significantly improved patient outcomes, and …
Immune activation correlates with and predicts CXCR4 co-receptor tropism switch in HIV-1 infection
BJ Connell, LE Hermans, AMJ Wensing, I Schellens… - Scientific reports, 2020 - nature.com
HIV-1 cell entry is mediated by binding to the CD4-receptor and chemokine co-receptors
CCR5 (R5) or CXCR4 (X4). R5-tropic viruses are predominantly detected during early …
CCR5 (R5) or CXCR4 (X4). R5-tropic viruses are predominantly detected during early …
Deep Sequencing of the HIV-1 env Gene Reveals Discrete X4 Lineages and Linkage Disequilibrium between X4 and R5 Viruses in the V1/V2 and V3 Variable …
ABSTRACT HIV-1 requires the CD4 receptor and a coreceptor (CCR5 [R5 phenotype] or
CXCR4 [X4 phenotype]) to enter cells. Coreceptor tropism can be assessed by either …
CXCR4 [X4 phenotype]) to enter cells. Coreceptor tropism can be assessed by either …
Deep sequencing of HIV: clinical and research applications
SB Chabria, S Gupta, MJ Kozal - Annual review of genomics …, 2014 - annualreviews.org
Human immunodeficiency virus (HIV) exhibits remarkable diversity in its genomic makeup
and exists in any given individual as a complex distribution of closely related but …
and exists in any given individual as a complex distribution of closely related but …
Next-generation sequencing to assess HIV tropism
LC Swenson, M Däumer, R Paredes - Current opinion in HIV and …, 2012 - journals.lww.com
Next-generation sequencing to assess HIV tropism : Current Opinion in HIV and AIDS Next-generation
sequencing to assess HIV tropism : Current Opinion in HIV and AIDS Log in or Register …
sequencing to assess HIV tropism : Current Opinion in HIV and AIDS Log in or Register …
Effect of HIV-1 subtype and tropism on treatment with chemokine coreceptor entry inhibitors; overview of viral entry inhibition
HIV-1 entry begins with viral envelope glycoprotein gp120 interacting with host-cell CD4 and
an entry coreceptor (mainly chemokine receptors CCR5 or CXCR4). Inhibitors of particular …
an entry coreceptor (mainly chemokine receptors CCR5 or CXCR4). Inhibitors of particular …
[HTML][HTML] HIV-1 adaptation to low levels of CCR5 results in V3 and V2 loop changes that increase envelope pathogenicity, CCR5 affinity and decrease susceptibility to …
Variability in CCR5 levels in the human population is suggested to affect virus evolution,
fitness and the course of HIV disease. We previously demonstrated that cell surface CCR5 …
fitness and the course of HIV disease. We previously demonstrated that cell surface CCR5 …
HIV-1 dual/mixed tropic isolates show different genetic and phenotypic characteristics and response to maraviroc in vitro
V Svicher, E Balestra, V Cento, L Sarmati, L Dori… - Antiviral research, 2011 - Elsevier
Dual/mixed-tropic HIV-1 strains are predominant in a significative proportion of patients,
though few information is available regarding the genetic characteristics, quasispecies …
though few information is available regarding the genetic characteristics, quasispecies …
Molecular gymnastics: mechanisms of HIV-1 resistance to CCR5 antagonists and impact on virus phenotypes
Human immunodeficiency virus type 1 (HIV-1) enters host cells through the binding of its
envelope glycoproteins (Env) to the host cell receptor CD4 and then subsequent binding to …
envelope glycoproteins (Env) to the host cell receptor CD4 and then subsequent binding to …