The skin forms an effective barrier between the organism and the environment preventing
invasion of pathogens and fending off chemical and physical assaults, as well as the …

Gap junctions allow the exchange of ions, second messengers, and small metabolites
between adjacent cells and are formed by two unrelated protein families, the pannexins and …

Skin is at the interface between the complex physiology of the body and the external, often
hostile, environment, and the semipermeable epidermal barrier prevents both the escape of …

We extended our previous genome-wide association study for psoriasis with a multistage
replication study including 8,312 individuals with psoriasis (cases) and 12,919 controls from …

Psoriasis is a common incurable inflammatory skin disease affecting 2–3% of the European
population. Psoriatic skin contains large numbers of immune cells which produce many …

The epidermis is a stratified epithelium that functions as a barrier protecting the organism
from dehydration, mechanical trauma, and microbial insults. This barrier function is …

Psoriasis is a T-cell-mediated chronic inflammatory skin disease believed to be of
autoimmune nature that can be triggered or worsened by streptococcal throat infections. In …

Mutations in patatin-like phospholipase domain-containing 1 (PNPLA1) cause autosomal
recessive congenital ichthyosis, but the mechanism involved remains unclear. Here we …

The percutaneous device dilemma describes etiological factors, centered around the
disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant …

Atopic dermatitis (AD) is characterized by epidermal tight junction (TJ) defects and a
propensity for Staphylococcus aureus skin infections. S. aureus is sensed by many pattern …