The CREB-binding protein (CREBBP, or in short CBP) and p300 are lysine (K) acetyl
transferases (KAT) belonging to the KAT3 family of proteins known to modify histones, as …

Oxymatrine (OMT) is a quinolizidine alkaloid derived from the roots of the Sophora genus
plants. It has been widely used as a treatment for chronic hepatitis infections and …

Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive types of cancer, is
characterized by aberrant activity of oncogenic KRAS. A nuclease-hypersensitive GC-rich …

Formation of G-quadruplex (G4) DNA structures in key regulatory regions in the genome has
emerged as a secondary structure-based epigenetic mechanism for regulating multiple …

Extrachromosomal circular DNA (eccDNA) are present within all eukaryotic organisms and
actively contribute to gene expression changes. MicroDNA (200-1000bp) are the most …

The susceptibility of cancer cells to different types of treatments can be restricted by intrinsic
and acquired therapeutic resistance, leading to the failure of cancer regression and …

Vascular endothelial cells are exposed to shear stresses with disturbed vs. laminar flow
patterns, which lead to proinflammatory vs. antiinflammatory phenotypes, respectively …

N-terminal acetylation is a major posttranslational modification in eukaryotes catalyzed by N-
terminal acetyltransferases (NATs), NatA through NatF. Although N-terminal acetylation …

Oxidative stress generated during inflammation is associated with a wide range of
pathologies. Resveratrol (RESV) displays anti-inflammatory and antioxidant activities, being …

The system of base excision repair (BER) ensures correction of the most abundant DNA
damages in mammalian cells and plays an important role in maintaining genome stability …