Polymyxins are valuable antimicrobials for the management of multidrug-resistant Gram-
negative bacteria; however, nephrotoxicity associated with these drugs is a very common …

Background Our aims were to evaluate critically the evidence from systematic reviews as
well as narrative reviews of the effects of melatonin (MLT) on health and to identify the …

Melatonin's pleiotropic actions begin from controlling day/night cycle and
hypothalamic/pituitary axes to, for example, vasomotor effects, immunomodulation, antilipid …

Abstract Purpose of Review Here, we review the known relations between hypertension and
obesity to inflammation and postulate the endogenous protective effect of melatonin and its …

Fibrosis is a common occurrence following organ injury and failure. To date, there is no
effective treatment for this condition. Melatonin targets numerous molecular pathways, a …

The “developmental origins of health and disease” theory indicates that many adult-onset
diseases can originate in the earliest stages of life. The developing kidney has emerged as …

Melatonin, widely used to counter transatlantic travel jet lag and insomnia, is synthesized in
the suprachiasmatic nucleus of the anterior pituitary gland. Its release into the circulation is …

Elevated heart rate is a risk factor for cardiovascular and all‐cause mortalities in the general
population and various cardiovascular pathologies. Insufficient heart rate decline during the …

Diabetes is one of the leading causes of chronic kidney disease (CKD), and multiple
underlying mechanisms involved in pathogenesis of diabetic nephropathy (DN) have been …

Obesity and associated diabetes (diabesity) impair kidney mitochondrial dynamics by
augmenting fission and diminishing fusion, which results in mitochondrial and renal …